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Acquired amphotericin B resistance leads to fitness trade-offs that can be mitigated by compensatory evolution in Candida auris.
Carolus H, Sofras D, Boccarella G, Sephton-Clark P, Biriukov V, Cauldron NC, Lobo Romero C, Vergauwen R, Yazdani S, Pierson S, Jacobs S, Vandecruys P, Wijnants S, Meis JF, Gabaldón T, van den Berg P, Rybak JM, Cuomo CA, Van Dijck P. Carolus H, et al. Among authors: sephton clark p. Nat Microbiol. 2024 Dec;9(12):3304-3320. doi: 10.1038/s41564-024-01854-z. Epub 2024 Nov 20. Nat Microbiol. 2024. PMID: 39567662
Similar evolutionary trajectories in an environmental Cryptococcus neoformans isolate after human and murine infection.
Sephton-Clark P, McConnell SA, Grossman N, Baker RP, Dragotakes Q, Fan Y, Fu MS, Gerbig G, Greengo S, Hardwick JM, Kulkarni M, Levitz SM, Nosanchuk JD, Shoham S, Smith DFQ, Stempinski P, Timp W, Wear MP, Cuomo CA, Casadevall A. Sephton-Clark P, et al. Proc Natl Acad Sci U S A. 2023 Jan 10;120(2):e2217111120. doi: 10.1073/pnas.2217111120. Epub 2023 Jan 5. Proc Natl Acad Sci U S A. 2023. PMID: 36603033 Free PMC article.
Genomic Variation across a Clinical Cryptococcus Population Linked to Disease Outcome.
Sephton-Clark P, Tenor JL, Toffaletti DL, Meyers N, Giamberardino C, Molloy SF, Palmucci JR, Chan A, Chikaonda T, Heyderman R, Hosseinipour M, Kalata N, Kanyama C, Kukacha C, Lupiya D, Mwandumba HC, Harrison T, Bicanic T, Perfect JR, Cuomo CA. Sephton-Clark P, et al. mBio. 2022 Dec 20;13(6):e0262622. doi: 10.1128/mbio.02626-22. Epub 2022 Nov 10. mBio. 2022. PMID: 36354332 Free PMC article.
A bacterial endosymbiont of the fungus Rhizopus microsporus drives phagocyte evasion and opportunistic virulence.
Itabangi H, Sephton-Clark PCS, Tamayo DP, Zhou X, Starling GP, Mahamoud Z, Insua I, Probert M, Correia J, Moynihan PJ, Gebremariam T, Gu Y, Ibrahim AS, Brown GD, King JS, Ballou ER, Voelz K. Itabangi H, et al. Among authors: sephton clark pcs. Curr Biol. 2022 Mar 14;32(5):1115-1130.e6. doi: 10.1016/j.cub.2022.01.028. Epub 2022 Feb 7. Curr Biol. 2022. PMID: 35134329 Free PMC article.
12 results