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Phase 1/2a clinical trial in ALS with ropinirole, a drug candidate identified by iPSC drug discovery.
Morimoto S, Takahashi S, Ito D, Daté Y, Okada K, Kato C, Nakamura S, Ozawa F, Chyi CM, Nishiyama A, Suzuki N, Fujimori K, Kondo T, Takao M, Hirai M, Kabe Y, Suematsu M, Jinzaki M, Aoki M, Fujiki Y, Sato Y, Suzuki N, Nakahara J; Pooled Resource Open-Access ALS Clinical Trials Consortium; Okano H. Morimoto S, et al. Among authors: suematsu m. Cell Stem Cell. 2023 Jun 1;30(6):766-780.e9. doi: 10.1016/j.stem.2023.04.017. Cell Stem Cell. 2023. PMID: 37267913 Free article. Clinical Trial.
Annexin A1 is a cell-intrinsic metalloregulator of zinc in human ILC2s.
Irie M, Kabata H, Sasahara K, Kurihara M, Shirasaki Y, Kamatani T, Baba R, Matsusaka M, Koga S, Masaki K, Miyata J, Araki Y, Kikawada T, Kabe Y, Suematsu M, Yamagishi M, Uemura S, Moro K, Fukunaga K. Irie M, et al. Among authors: suematsu m. Cell Rep. 2023 Jun 27;42(6):112610. doi: 10.1016/j.celrep.2023.112610. Epub 2023 Jun 7. Cell Rep. 2023. PMID: 37294636 Free article.
Shared GABA transmission pathology in dopamine agonist- and antagonist-induced dyskinesia.
Abe Y, Yagishita S, Sano H, Sugiura Y, Dantsuji M, Suzuki T, Mochizuki A, Yoshimaru D, Hata J, Matsumoto M, Taira S, Takeuchi H, Okano H, Ohno N, Suematsu M, Inoue T, Nambu A, Watanabe M, Tanaka KF. Abe Y, et al. Among authors: suematsu m. Cell Rep Med. 2023 Oct 17;4(10):101208. doi: 10.1016/j.xcrm.2023.101208. Epub 2023 Sep 28. Cell Rep Med. 2023. PMID: 37774703 Free PMC article.
SDHAF1 confers metabolic resilience to aging hematopoietic stem cells by promoting mitochondrial ATP production.
Watanuki S, Kobayashi H, Sugiura Y, Yamamoto M, Karigane D, Shiroshita K, Sorimachi Y, Morikawa T, Fujita S, Shide K, Haraguchi M, Tamaki S, Mikawa T, Kondoh H, Nakano H, Sumiyama K, Nagamatsu G, Goda N, Okamoto S, Nakamura-Ishizu A, Shimoda K, Suematsu M, Suda T, Takubo K. Watanuki S, et al. Among authors: suematsu m. Cell Stem Cell. 2024 Aug 1;31(8):1145-1161.e15. doi: 10.1016/j.stem.2024.04.023. Epub 2024 May 20. Cell Stem Cell. 2024. PMID: 38772377
Cellular senescence induction leads to progressive cell death via the INK4a-RB pathway in naked mole-rats.
Kawamura Y, Oka K, Semba T, Takamori M, Sugiura Y, Yamasaki R, Suzuki Y, Chujo T, Nagase M, Oiwa Y, Fujioka S, Homma S, Yamamura Y, Miyawaki S, Narita M, Fukuda T, Sakai Y, Ishimoto T, Tomizawa K, Suematsu M, Yamamoto T, Bono H, Okano H, Miura K. Kawamura Y, et al. Among authors: suematsu m. EMBO J. 2023 Aug 15;42(16):e111133. doi: 10.15252/embj.2022111133. Epub 2023 Jul 11. EMBO J. 2023. PMID: 37431790 Free PMC article.
Pathology and gene mutations of aldosterone-producing lesions.
Nishimoto K, Ogishima T, Sugiura Y, Suematsu M, Mukai K. Nishimoto K, et al. Among authors: suematsu m. Endocr J. 2023 Dec 28;70(12):1113-1122. doi: 10.1507/endocrj.EJ22-0492. Epub 2023 Sep 26. Endocr J. 2023. PMID: 37766569 Free article. Review.
Context-dependent modification of PFKFB3 in hematopoietic stem cells promotes anaerobic glycolysis and ensures stress hematopoiesis.
Watanuki S, Kobayashi H, Sugiura Y, Yamamoto M, Karigane D, Shiroshita K, Sorimachi Y, Fujita S, Morikawa T, Koide S, Oshima M, Nishiyama A, Murakami K, Haraguchi M, Tamaki S, Yamamoto T, Yabushita T, Tanaka Y, Nagamatsu G, Honda H, Okamoto S, Goda N, Tamura T, Nakamura-Ishizu A, Suematsu M, Iwama A, Suda T, Takubo K. Watanuki S, et al. Among authors: suematsu m. Elife. 2024 Apr 4;12:RP87674. doi: 10.7554/eLife.87674. Elife. 2024. PMID: 38573813 Free PMC article.
536 results