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Therapeutic blood-brain barrier modulation and stroke treatment by a bioengineered FZD4-selective WNT surrogate in mice.
Ding J, Lee SJ, Vlahos L, Yuki K, Rada CC, van Unen V, Vuppalapaty M, Chen H, Sura A, McCormick AK, Tomaske M, Alwahabi S, Nguyen H, Nowatzke W, Kim L, Kelly L, Vollrath D, Califano A, Yeh WC, Li Y, Kuo CJ. Ding J, et al. Among authors: chen h. Nat Commun. 2023 Jun 2;14(1):2947. doi: 10.1038/s41467-023-37689-1. Nat Commun. 2023. PMID: 37268690 Free PMC article.
Tissue-targeted R-spondin mimetics for liver regeneration.
Zhang Z, Broderick C, Nishimoto M, Yamaguchi T, Lee SJ, Zhang H, Chen H, Patel M, Ye J, Ponce A, Brady J, Baribault H, Li Y, Yeh WC. Zhang Z, et al. Among authors: chen h. Sci Rep. 2020 Aug 18;10(1):13951. doi: 10.1038/s41598-020-70912-3. Sci Rep. 2020. PMID: 32811902 Free PMC article.
Development of selective bispecific Wnt mimetics for bone loss and repair.
Fowler TW, Mitchell TL, Janda CY, Xie L, Tu S, Chen H, Zhang H, Ye J, Ouyang B, Yuan TZ, Lee SJ, Newman M, Tripuraneni N, Rego ES, Mutha D, Dilip A, Vuppalapaty M, Baribault H, Yeh WC, Li Y. Fowler TW, et al. Among authors: chen h. Nat Commun. 2021 May 31;12(1):3247. doi: 10.1038/s41467-021-23374-8. Nat Commun. 2021. PMID: 34059688 Free PMC article.
Robust Colonic Epithelial Regeneration and Amelioration of Colitis via FZD-Specific Activation of Wnt Signaling.
Xie L, Fletcher RB, Bhatia D, Shah D, Phipps J, Deshmukh S, Zhang H, Ye J, Lee S, Le L, Newman M, Chen H, Sura A, Gupta S, Sanman LE, Yang F, Meng W, Baribault H, Vanhove GF, Yeh WC, Li Y, Lu C. Xie L, et al. Among authors: chen h. Cell Mol Gastroenterol Hepatol. 2022;14(2):435-464. doi: 10.1016/j.jcmgh.2022.05.003. Epub 2022 May 13. Cell Mol Gastroenterol Hepatol. 2022. PMID: 35569814 Free PMC article.
Novel Frizzled-specific antibody-based Wnt mimetics and Wnt superagonists selectively activate WNT/β-catenin signaling in target tissues.
Post Y, Dilip A, Xie L, Sura A, Suen N, Ye J, Mutha D, Liu AT, Nguyen H, Whisler E, Shah D, Deshmukh S, Dhaliwal N, Bauer B, Nigatu E, Diep A, Lopez T, Fowler TW, Lee SJ, Lu C, Yeh WC, Chen H, Li Y. Post Y, et al. Among authors: chen h. Cell Chem Biol. 2023 Aug 17;30(8):976-986.e5. doi: 10.1016/j.chembiol.2023.06.006. Epub 2023 Jul 5. Cell Chem Biol. 2023. PMID: 37413985 Free article.
BRAIDing receptors for cell-specific targeting.
Chen H, Lee SJ, Li R, Sura A, Suen N, Dilip A, Pomogov Y, Vuppalapaty M, Suen TT, Lu C, Post Y, Li Y. Chen H, et al. Elife. 2024 Jan 9;12:RP90221. doi: 10.7554/eLife.90221. Elife. 2024. PMID: 38193894 Free PMC article.
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