Zhang Q - Search Results

1

Structural insights into ligand recognition and activation of the medium-chain fatty acid-sensing receptor GPR84.

Liu H, Zhang Q, He X, Jiang M, Wang S, Yan X, Cheng X, Liu Y, Nan FJ, Xu HE, Xie X, Yin W. Liu H, et al. Among authors: zhang q. Nat Commun. 2023 Jun 6;14(1):3271. doi: 10.1038/s41467-023-38985-6. Nat Commun. 2023. PMID: 37277332 Free PMC article.

2

Discovery and Characterization of a Novel Small-Molecule Agonist for Medium-Chain Free Fatty Acid Receptor G Protein-Coupled Receptor 84.

Zhang Q, Yang H, Li J, Xie X. Zhang Q, et al. J Pharmacol Exp Ther. 2016 May;357(2):337-44. doi: 10.1124/jpet.116.232033. Epub 2016 Mar 9. J Pharmacol Exp Ther. 2016. PMID: 26962172

3

Design and Synthesis of 2-Alkylpyrimidine-4,6-diol and 6-Alkylpyridine-2,4-diol as Potent GPR84 Agonists.

Liu Y, Zhang Q, Chen LH, Yang H, Lu W, Xie X, Nan FJ. Liu Y, et al. Among authors: zhang q. ACS Med Chem Lett. 2016 Mar 30;7(6):579-83. doi: 10.1021/acsmedchemlett.6b00025. eCollection 2016 Jun 9. ACS Med Chem Lett. 2016. PMID: 27326330 Free PMC article.

4

Modulation of the G-Protein-Coupled Receptor 84 (GPR84) by Agonists and Antagonists.

Chen LH, Zhang Q, Xie X, Nan FJ. Chen LH, et al. Among authors: zhang q. J Med Chem. 2020 Dec 24;63(24):15399-15409. doi: 10.1021/acs.jmedchem.0c01378. Epub 2020 Dec 2. J Med Chem. 2020. PMID: 33267584

5

GPR84 signaling promotes intestinal mucosal inflammation via enhancing NLRP3 inflammasome activation in macrophages.

Zhang Q, Chen LH, Yang H, Fang YC, Wang SW, Wang M, Yuan QT, Wu W, Zhang YM, Liu ZJ, Nan FJ, Xie X. Zhang Q, et al. Among authors: zhang ym. Acta Pharmacol Sin. 2022 Aug;43(8):2042-2054. doi: 10.1038/s41401-021-00825-y. Epub 2021 Dec 15. Acta Pharmacol Sin. 2022. PMID: 34912006 Free PMC article.

6

Phosphodiesters as GPR84 Antagonists for the Treatment of Ulcerative Colitis.

Chen LH, Zhang Q, Xiao YF, Fang YC, Xie X, Nan FJ. Chen LH, et al. Among authors: zhang q. J Med Chem. 2022 Mar 10;65(5):3991-4006. doi: 10.1021/acs.jmedchem.1c01813. Epub 2022 Feb 23. J Med Chem. 2022. PMID: 35195005

7

Loss of MLKL ameliorates liver fibrosis by inhibiting hepatocyte necroptosis and hepatic stellate cell activation.

Guo R, Jia X, Ding Z, Wang G, Jiang M, Li B, Chen S, Xia B, Zhang Q, Liu J, Zheng R, Gao Z, Xie X. Guo R, et al. Among authors: zhang q. Theranostics. 2022 Jul 4;12(11):5220-5236. doi: 10.7150/thno.71400. eCollection 2022. Theranostics. 2022. PMID: 35836819 Free PMC article.

8

GPR84 regulates pulmonary inflammation by modulating neutrophil functions.

Wang SW, Zhang Q, Lu D, Fang YC, Yan XC, Chen J, Xia ZK, Yuan QT, Chen LH, Zhang YM, Nan FJ, Xie X. Wang SW, et al. Among authors: zhang ym, zhang q. Acta Pharmacol Sin. 2023 Aug;44(8):1665-1675. doi: 10.1038/s41401-023-01080-z. Epub 2023 Apr 4. Acta Pharmacol Sin. 2023. PMID: 37016043 Free PMC article.

9

Unsymmetrical Phosphodiesters as GPR84 Antagonists with High Blood Exposure for the Treatment of Lung Inflammation.

Li SX, Wang SW, Chen LH, Zhang Q, Lu D, Chen J, Fang YC, Gu M, Xie X, Nan FJ. Li SX, et al. Among authors: zhang q. J Med Chem. 2023 Apr 27;66(8):5820-5838. doi: 10.1021/acs.jmedchem.3c00053. Epub 2023 Apr 13. J Med Chem. 2023. PMID: 37053384

10

Author Correction: Structural insights into ligand recognition and activation of the medium-chain fatty acid-sensing receptor GPR84.

Liu H, Zhang Q, He X, Jiang M, Wang S, Yan X, Cheng X, Liu Y, Nan FJ, Xu HE, Xie X, Yin W. Liu H, et al. Among authors: zhang q. Nat Commun. 2023 Jul 5;14(1):3974. doi: 10.1038/s41467-023-39757-y. Nat Commun. 2023. PMID: 37407619 Free PMC article. No abstract available.

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