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A Phase Ib Study Assessing the Safety, Tolerability, and Efficacy of the First-in-Class Wee1 Inhibitor Adavosertib (AZD1775) as Monotherapy in Patients with Advanced Solid Tumors.
Bauer TM, Moore KN, Rader JS, Simpkins F, Mita AC, Beck JT, Hart L, Chu Q, Oza A, Tinker AV, Imedio ER, Kumar S, Mugundu G, Jenkins S, Chmielecki J, Jones S, Spigel D, Fu S. Bauer TM, et al. Among authors: simpkins f. Target Oncol. 2023 Jul;18(4):517-530. doi: 10.1007/s11523-023-00965-7. Epub 2023 Jun 6. Target Oncol. 2023. PMID: 37278879 Free PMC article. Clinical Trial.
Cisplatin resistance in human cervical, ovarian and lung cancer cells.
Chen J, Solomides C, Parekh H, Simpkins F, Simpkins H. Chen J, et al. Among authors: simpkins f, simpkins h. Cancer Chemother Pharmacol. 2015 Jun;75(6):1217-27. doi: 10.1007/s00280-015-2739-2. Epub 2015 Apr 18. Cancer Chemother Pharmacol. 2015. PMID: 25894720
Src Inhibition with saracatinib reverses fulvestrant resistance in ER-positive ovarian cancer models in vitro and in vivo.
Simpkins F, Hevia-Paez P, Sun J, Ullmer W, Gilbert CA, da Silva T, Pedram A, Levin ER, Reis IM, Rabinovich B, Azzam D, Xu XX, Ince TA, Yang JY, Verhaak RG, Lu Y, Mills GB, Slingerland JM. Simpkins F, et al. Clin Cancer Res. 2012 Nov 1;18(21):5911-23. doi: 10.1158/1078-0432.CCR-12-1257. Epub 2012 Aug 15. Clin Cancer Res. 2012. PMID: 22896656 Free PMC article.
The role of Nrf2 and ATF2 in resistance to platinum-based chemotherapy.
Chen J, Solomides C, Simpkins F, Simpkins H. Chen J, et al. Among authors: simpkins f, simpkins h. Cancer Chemother Pharmacol. 2017 Feb;79(2):369-380. doi: 10.1007/s00280-016-3225-1. Epub 2017 Jan 24. Cancer Chemother Pharmacol. 2017. PMID: 28120035
70 results