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Functional gene delivery to and across brain vasculature of systemic AAVs with endothelial-specific tropism in rodents and broad tropism in primates.
Chen X, Wolfe DA, Bindu DS, Zhang M, Taskin N, Goertsen D, Shay TF, Sullivan EE, Huang SF, Ravindra Kumar S, Arokiaraj CM, Plattner VM, Campos LJ, Mich JK, Monet D, Ngo V, Ding X, Omstead V, Weed N, Bishaw Y, Gore BB, Lein ES, Akrami A, Miller C, Levi BP, Keller A, Ting JT, Fox AS, Eroglu C, Gradinaru V. Chen X, et al. Among authors: huang sf. Nat Commun. 2023 Jun 8;14(1):3345. doi: 10.1038/s41467-023-38582-7. Nat Commun. 2023. PMID: 37291094 Free PMC article.
The Interplay Between Brain Vascular Calcification and Microglia.
Maheshwari U, Huang SF, Sridhar S, Keller A. Maheshwari U, et al. Among authors: huang sf. Front Aging Neurosci. 2022 Mar 2;14:848495. doi: 10.3389/fnagi.2022.848495. eCollection 2022. Front Aging Neurosci. 2022. PMID: 35309892 Free PMC article. Review.
Functional gene delivery to and across brain vasculature of systemic AAVs with endothelial-specific tropism in rodents and broad tropism in primates.
Chen X, Wolfe DA, Bindu DS, Zhang M, Taskin N, Goertsen D, Shay TF, Sullivan E, Huang SF, Kumar SR, Arokiaraj CM, Plattner V, Campos LJ, Mich J, Monet D, Ngo V, Ding X, Omstead V, Weed N, Bishaw Y, Gore B, Lein ES, Akrami A, Miller C, Levi BP, Keller A, Ting JT, Fox AS, Eroglu C, Gradinaru V. Chen X, et al. Among authors: huang sf. bioRxiv [Preprint]. 2023 Jan 13:2023.01.12.523844. doi: 10.1101/2023.01.12.523844. bioRxiv. 2023. Update in: Nat Commun. 2023 Jun 8;14(1):3345. doi: 10.1038/s41467-023-38582-7 PMID: 36711773 Free PMC article. Updated. Preprint.
Targeting TREM2 signaling shows limited impact on cerebrovascular calcification.
Sridhar S, Zhou Y, Ibrahim A, Bertazzo S, Wyss T, Swain A, Maheshwari U, Huang SF, Colonna M, Keller A. Sridhar S, et al. Among authors: huang sf. Life Sci Alliance. 2024 Oct 28;8(1):e202402796. doi: 10.26508/lsa.202402796. Print 2025 Jan. Life Sci Alliance. 2024. PMID: 39467636 Free PMC article.
Inorganic phosphate exporter heterozygosity in mice leads to brain vascular calcification, microangiopathy, and microgliosis.
Maheshwari U, Mateos JM, Weber-Stadlbauer U, Ni R, Tamatey V, Sridhar S, Restrepo A, de Jong PA, Huang SF, Schaffenrath J, Stifter SA, Szeri F, Greter M, Koek HL, Keller A. Maheshwari U, et al. Among authors: huang sf. Brain Pathol. 2023 Nov;33(6):e13189. doi: 10.1111/bpa.13189. Epub 2023 Jul 28. Brain Pathol. 2023. PMID: 37505935 Free PMC article.
Astrocyte glutathione maintains endothelial barrier stability.
Huang SF, Othman A, Koshkin A, Fischer S, Fischer D, Zamboni N, Ono K, Sawa T, Ogunshola OO. Huang SF, et al. Redox Biol. 2020 Jul;34:101576. doi: 10.1016/j.redox.2020.101576. Epub 2020 May 19. Redox Biol. 2020. PMID: 32502899 Free PMC article.
857 results