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841 results

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Chronic activation of tubulin tyrosination in HCM mice and human iPSC-engineered heart tissues improves heart function.
Pietsch N, Chen CY, Kupsch S, Bacmeister L, Geertz B, Herera-Rivero M, Voß H, Krämer E, Braren I, Westermann D, Schlüter H, Mearini G, Schlossarek S, van der Velden J, Caporizzo MA, Lindner D, Prosser BL, Carrier L. Pietsch N, et al. Among authors: kramer e. bioRxiv [Preprint]. 2024 Feb 7:2023.05.25.542365. doi: 10.1101/2023.05.25.542365. bioRxiv. 2024. Update in: Circ Res. 2024 Oct 11;135(9):910-932. doi: 10.1161/CIRCRESAHA.124.324387 PMID: 37292763 Free PMC article. Updated. Preprint.
Nonsense-mediated mRNA decay and ubiquitin-proteasome system regulate cardiac myosin-binding protein C mutant levels in cardiomyopathic mice.
Vignier N, Schlossarek S, Fraysse B, Mearini G, Krämer E, Pointu H, Mougenot N, Guiard J, Reimer R, Hohenberg H, Schwartz K, Vernet M, Eschenhagen T, Carrier L. Vignier N, et al. Among authors: kramer e. Circ Res. 2009 Jul 31;105(3):239-48. doi: 10.1161/CIRCRESAHA.109.201251. Epub 2009 Jul 9. Circ Res. 2009. PMID: 19590044
Atrogin-1 and MuRF1 regulate cardiac MyBP-C levels via different mechanisms.
Mearini G, Gedicke C, Schlossarek S, Witt CC, Krämer E, Cao P, Gomes MD, Lecker SH, Labeit S, Willis MS, Eschenhagen T, Carrier L. Mearini G, et al. Among authors: kramer e. Cardiovasc Res. 2010 Jan 15;85(2):357-66. doi: 10.1093/cvr/cvp348. Epub 2009 Oct 22. Cardiovasc Res. 2010. PMID: 19850579 Free PMC article.
Increased myofilament Ca2+ sensitivity and diastolic dysfunction as early consequences of Mybpc3 mutation in heterozygous knock-in mice.
Fraysse B, Weinberger F, Bardswell SC, Cuello F, Vignier N, Geertz B, Starbatty J, Krämer E, Coirault C, Eschenhagen T, Kentish JC, Avkiran M, Carrier L. Fraysse B, et al. Among authors: kramer e. J Mol Cell Cardiol. 2012 Jun;52(6):1299-307. doi: 10.1016/j.yjmcc.2012.03.009. Epub 2012 Mar 23. J Mol Cell Cardiol. 2012. PMID: 22465693 Free PMC article.
Repair of Mybpc3 mRNA by 5'-trans-splicing in a Mouse Model of Hypertrophic Cardiomyopathy.
Mearini G, Stimpel D, Krämer E, Geertz B, Braren I, Gedicke-Hornung C, Précigout G, Müller OJ, Katus HA, Eschenhagen T, Voit T, Garcia L, Lorain S, Carrier L. Mearini G, et al. Among authors: kramer e. Mol Ther Nucleic Acids. 2013 Jul 2;2(7):e102. doi: 10.1038/mtna.2013.31. Mol Ther Nucleic Acids. 2013. PMID: 23820890 Free PMC article.
The E3 ubiquitin ligase Asb2β is downregulated in a mouse model of hypertrophic cardiomyopathy and targets desmin for proteasomal degradation.
Thottakara T, Friedrich FW, Reischmann S, Braumann S, Schlossarek S, Krämer E, Juhr D, Schlüter H, van der Velden J, Münch J, Patten M, Eschenhagen T, Moog-Lutz C, Carrier L. Thottakara T, et al. Among authors: kramer e. J Mol Cell Cardiol. 2015 Oct;87:214-24. doi: 10.1016/j.yjmcc.2015.08.020. Epub 2015 Sep 3. J Mol Cell Cardiol. 2015. PMID: 26343497
Evaluation of MYBPC3 trans-Splicing and Gene Replacement as Therapeutic Options in Human iPSC-Derived Cardiomyocytes.
Prondzynski M, Krämer E, Laufer SD, Shibamiya A, Pless O, Flenner F, Müller OJ, Münch J, Redwood C, Hansen A, Patten M, Eschenhagen T, Mearini G, Carrier L. Prondzynski M, et al. Among authors: kramer e. Mol Ther Nucleic Acids. 2017 Jun 16;7:475-486. doi: 10.1016/j.omtn.2017.05.008. Epub 2017 May 17. Mol Ther Nucleic Acids. 2017. PMID: 28624223 Free PMC article.
Activation of Autophagy Ameliorates Cardiomyopathy in Mybpc3-Targeted Knockin Mice.
Singh SR, Zech ATL, Geertz B, Reischmann-Düsener S, Osinska H, Prondzynski M, Krämer E, Meng Q, Redwood C, van der Velden J, Robbins J, Schlossarek S, Carrier L. Singh SR, et al. Among authors: kramer e. Circ Heart Fail. 2017 Oct;10(10):e004140. doi: 10.1161/CIRCHEARTFAILURE.117.004140. Circ Heart Fail. 2017. PMID: 29021349 Free PMC article.
841 results