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PET imaging in rat brain shows opposite effects of acute and chronic alcohol exposure on phosphodiesterase-4B, an indirect biomarker of cAMP activity.
Tang S, Kim SW, Olsen-Dufour A, Pearson T, Freaney M, Singley E, Jenkins M, Burkard NJ, Wozniak A, Parcon P, Wu S, Morse CL, Jana S, Liow JS, Zoghbi SS, Vendruscolo JCM, Vendruscolo LF, Pike VW, Koob GF, Volkow ND, Innis RB. Tang S, et al. Among authors: vendruscolo jcm. Neuropsychopharmacology. 2024 Dec;50(2):444-451. doi: 10.1038/s41386-024-01988-y. Epub 2024 Sep 16. Neuropsychopharmacology. 2024. PMID: 39285225 Free PMC article.
Genetic or pharmacological GHSR blockade has sexually dimorphic effects in rodents on a high-fat diet.
Lékó AH, Gregory-Flores A, Marchette RCN, Gomez JL, Vendruscolo JCM, Repunte-Canonigo V, Choung V, Deschaine SL, Whiting KE, Jackson SN, Cornejo MP, Perello M, You ZB, Eckhaus M, Rasineni K, Janda KD, Zorman B, Sumazin P, Koob GF, Michaelides M, Sanna PP, Vendruscolo LF, Leggio L. Lékó AH, et al. Among authors: vendruscolo jcm. Commun Biol. 2024 May 25;7(1):632. doi: 10.1038/s42003-024-06303-5. Commun Biol. 2024. PMID: 38796563 Free PMC article.
Ketone Supplementation Dampens Subjective and Objective Responses to Alcohol: Evidence From a Preclinical Rat Study and a Randomized, Cross-Over Trial in Healthy Volunteers.
Li X, Shi Z, Todaro DR, Pond T, Byanyima JI, Vesslee SA, Reddy R, Nanga RPR, Kass G, Ramchandani V, Kranzler HR, Vendruscolo JCM, Vendruscolo LF, Wiers CE. Li X, et al. Among authors: vendruscolo jcm. Int J Neuropsychopharmacol. 2024 Feb 1;27(2):pyae009. doi: 10.1093/ijnp/pyae009. Int J Neuropsychopharmacol. 2024. PMID: 38315678 Free PMC article. Clinical Trial.
Genetic or pharmacological GHSR blockade has sexually dimorphic effects in rodents on a high-fat diet.
Leggio L, Leko A, Gregory-Flores A, Marchette R, Gomez J, Vendruscolo J, Repunte-Canonigo V, Chuong V, Deschaine S, Whiting K, Jackson S, Cornejo M, Perello M, You ZB, Eckhaus M, Janda K, Zorman B, Sumazin P, Koob G, Michaelides M, Sanna PP, Vendruscolo L. Leggio L, et al. Among authors: vendruscolo j. Res Sq [Preprint]. 2023 Oct 18:rs.3.rs-3236045. doi: 10.21203/rs.3.rs-3236045/v1. Res Sq. 2023. Update in: Commun Biol. 2024 May 25;7(1):632. doi: 10.1038/s42003-024-06303-5 PMID: 37886546 Free PMC article. Updated. Preprint.
Ketone supplementation dampens subjective and objective responses to alcohol in rats and humans.
Li X, Shi Z, Todaro D, Pond T, Byanyima J, Vesslee S, Reddy R, Reddy Nanga RP, Kass G, Ramchandani V, Kranzler HR, Vendruscolo JCM, Vendruscolo LF, Wiers CE. Li X, et al. Among authors: vendruscolo jcm. bioRxiv [Preprint]. 2023 Sep 23:2023.09.23.558269. doi: 10.1101/2023.09.23.558269. bioRxiv. 2023. Update in: Int J Neuropsychopharmacol. 2024 Feb 1;27(2):pyae009. doi: 10.1093/ijnp/pyae009 PMID: 37790364 Free PMC article. Updated. Preprint.
Heroin- and Fentanyl-Induced Respiratory Depression in a Rat Plethysmography Model: Potency, Tolerance, and Sex Differences.
Marchette RCN, Carlson ER, Frye EV, Hastings LE, Vendruscolo JCM, Mejias-Torres G, Lewis SJ, Hampson A, Volkow ND, Vendruscolo LF, Koob GF. Marchette RCN, et al. Among authors: vendruscolo jcm. J Pharmacol Exp Ther. 2023 May;385(2):117-134. doi: 10.1124/jpet.122.001476. Epub 2023 Feb 24. J Pharmacol Exp Ther. 2023. PMID: 36828628 Free PMC article.
27 results