Miton CM - Search Results

1

Molecular determinants of protein evolvability.

Buda K, Miton CM, Fan XC, Tokuriki N. Buda K, et al. Among authors: miton cm. Trends Biochem Sci. 2023 Sep;48(9):751-760. doi: 10.1016/j.tibs.2023.05.009. Epub 2023 Jun 15. Trends Biochem Sci. 2023. PMID: 37330341 Review.

2

How mutational epistasis impairs predictability in protein evolution and design.

Miton CM, Tokuriki N. Miton CM, et al. Protein Sci. 2016 Jul;25(7):1260-72. doi: 10.1002/pro.2876. Epub 2016 Jan 22. Protein Sci. 2016. PMID: 26757214 Free PMC article.

3

A mechanistic view of enzyme evolution.

Yang G, Miton CM, Tokuriki N. Yang G, et al. Among authors: miton cm. Protein Sci. 2020 Aug;29(8):1724-1747. doi: 10.1002/pro.3901. Protein Sci. 2020. PMID: 32557882 Free PMC article. Review.

4

Statistical analysis of mutational epistasis to reveal intramolecular interaction networks in proteins.

Miton CM, Chen JZ, Ost K, Anderson DW, Tokuriki N. Miton CM, et al. Methods Enzymol. 2020;643:243-280. doi: 10.1016/bs.mie.2020.07.012. Epub 2020 Aug 25. Methods Enzymol. 2020. PMID: 32896284

5

Epistasis and intramolecular networks in protein evolution.

Miton CM, Buda K, Tokuriki N. Miton CM, et al. Curr Opin Struct Biol. 2021 Aug;69:160-168. doi: 10.1016/j.sbi.2021.04.007. Epub 2021 May 30. Curr Opin Struct Biol. 2021. PMID: 34077895 Review.

6

Insertions and Deletions (Indels): A Missing Piece of the Protein Engineering Jigsaw.

Miton CM, Tokuriki N. Miton CM, et al. Biochemistry. 2023 Jan 17;62(2):148-157. doi: 10.1021/acs.biochem.2c00188. Epub 2022 Jul 13. Biochemistry. 2023. PMID: 35830609 Review.

7

Cryptic genetic variation shapes the adaptive evolutionary potential of enzymes.

Baier F, Hong N, Yang G, Pabis A, Miton CM, Barrozo A, Carr PD, Kamerlin SC, Jackson CJ, Tokuriki N. Baier F, et al. Among authors: miton cm. Elife. 2019 Feb 5;8:e40789. doi: 10.7554/eLife.40789. Elife. 2019. PMID: 30719972 Free PMC article.

8

Evolutionary repurposing of a sulfatase: A new Michaelis complex leads to efficient transition state charge offset.

Miton CM, Jonas S, Fischer G, Duarte F, Mohamed MF, van Loo B, Kintses B, Kamerlin SCL, Tokuriki N, Hyvönen M, Hollfelder F. Miton CM, et al. Proc Natl Acad Sci U S A. 2018 Jul 31;115(31):E7293-E7302. doi: 10.1073/pnas.1607817115. Epub 2018 Jul 16. Proc Natl Acad Sci U S A. 2018. PMID: 30012610 Free PMC article.

9

Mechanistic Understanding Enables the Rational Design of Salicylanilide Combination Therapies for Gram-Negative Infections.

Copp JN, Pletzer D, Brown AS, Van der Heijden J, Miton CM, Edgar RJ, Rich MH, Little RF, Williams EM, Hancock REW, Tokuriki N, Ackerley DF. Copp JN, et al. Among authors: miton cm. mBio. 2020 Sep 15;11(5):e02068-20. doi: 10.1128/mBio.02068-20. mBio. 2020. PMID: 32934086 Free PMC article.

10

Pervasive epistasis exposes intramolecular networks in adaptive enzyme evolution.

Buda K, Miton CM, Tokuriki N. Buda K, et al. Among authors: miton cm. Nat Commun. 2023 Dec 21;14(1):8508. doi: 10.1038/s41467-023-44333-5. Nat Commun. 2023. PMID: 38129396 Free PMC article.

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