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Development and biophysical characterization of a humanized FSH-blocking monoclonal antibody therapeutic formulated at an ultra-high concentration.
Rojekar S, Pallapati AR, Gimenez-Roig J, Korkmaz F, Sultana F, Sant D, Haeck CM, Macdonald A, Kim SM, Rosen CJ, Barak O, Meseck M, Caminis J, Lizneva D, Yuen T, Zaidi M. Rojekar S, et al. Among authors: yuen t. Elife. 2023 Jun 19;12:e88898. doi: 10.7554/eLife.88898. Elife. 2023. PMID: 37334968 Free PMC article.
Blocking FSH action attenuates osteoclastogenesis.
Zhu LL, Tourkova I, Yuen T, Robinson LJ, Bian Z, Zaidi M, Blair HC. Zhu LL, et al. Among authors: yuen t. Biochem Biophys Res Commun. 2012 May 25;422(1):54-8. doi: 10.1016/j.bbrc.2012.04.104. Epub 2012 Apr 27. Biochem Biophys Res Commun. 2012. PMID: 22561017 Free PMC article.
Bone marrow oxytocin mediates the anabolic action of estrogen on the skeleton.
Colaianni G, Sun L, Di Benedetto A, Tamma R, Zhu LL, Cao J, Grano M, Yuen T, Colucci S, Cuscito C, Mancini L, Li J, Nishimori K, Bab I, Lee HJ, Iqbal J, Young WS 3rd, Rosen C, Zallone A, Zaidi M. Colaianni G, et al. Among authors: yuen t. J Biol Chem. 2012 Aug 17;287(34):29159-67. doi: 10.1074/jbc.M112.365049. Epub 2012 Jul 2. J Biol Chem. 2012. PMID: 22761429 Free PMC article.
Blocking antibody to the β-subunit of FSH prevents bone loss by inhibiting bone resorption and stimulating bone synthesis.
Zhu LL, Blair H, Cao J, Yuen T, Latif R, Guo L, Tourkova IL, Li J, Davies TF, Sun L, Bian Z, Rosen C, Zallone A, New MI, Zaidi M. Zhu LL, et al. Among authors: yuen t. Proc Natl Acad Sci U S A. 2012 Sep 4;109(36):14574-9. doi: 10.1073/pnas.1212806109. Epub 2012 Aug 20. Proc Natl Acad Sci U S A. 2012. PMID: 22908268 Free PMC article.
Beyond Reproduction: Pituitary Hormone Actions on Bone.
Yuen T, Sun L, Liu P, Blair HC, New M, Zallone A, Zaidi M. Yuen T, et al. Prog Mol Biol Transl Sci. 2016;143:175-185. doi: 10.1016/bs.pmbts.2016.08.004. Epub 2016 Sep 7. Prog Mol Biol Transl Sci. 2016. PMID: 27697202 Review.
375 results