Roy MJ - Search Results

1

Structural mapping of PEAK pseudokinase interactions identifies 14-3-3 as a molecular switch for PEAK3 signaling.

Roy MJ, Surudoi MG, Kropp A, Hou J, Dai W, Hardy JM, Liang LY, Cotton TR, Lechtenberg BC, Dite TA, Ma X, Daly RJ, Patel O, Lucet IS. Roy MJ, et al. Nat Commun. 2023 Jun 19;14(1):3542. doi: 10.1038/s41467-023-38869-9. Nat Commun. 2023. PMID: 37336884 Free PMC article.

2

The PEAK family of pseudokinases, their role in cell signalling and cancer.

Patel O, Roy MJ, Murphy JM, Lucet IS. Patel O, et al. Among authors: roy mj. FEBS J. 2020 Oct;287(19):4183-4197. doi: 10.1111/febs.15087. Epub 2019 Nov 6. FEBS J. 2020. PMID: 31599110 Free article. Review.

3

The intracellular domains of the EphB6 and EphA10 receptor tyrosine pseudokinases function as dynamic signalling hubs.

Liang LY, Roy M, Horne CR, Sandow JJ, Surudoi M, Dagley LF, Young SN, Dite T, Babon JJ, Janes PW, Patel O, Murphy JM, Lucet IS. Liang LY, et al. Biochem J. 2021 Sep 17;478(17):3351-3371. doi: 10.1042/BCJ20210572. Biochem J. 2021. PMID: 34431498 Free PMC article.

4

Structural basis for small molecule targeting of Doublecortin Like Kinase 1 with DCLK1-IN-1.

Patel O, Roy MJ, Kropp A, Hardy JM, Dai W, Lucet IS. Patel O, et al. Among authors: roy mj. Commun Biol. 2021 Sep 20;4(1):1105. doi: 10.1038/s42003-021-02631-y. Commun Biol. 2021. PMID: 34545159 Free PMC article.

5

Distinct PEAK3 interactors and outputs expand the signaling potential of the PEAK pseudokinase family.

Hou J, Nguyen EV, Surudoi M, Roy MJ, Patel O, Lucet IS, Ma X, Daly RJ. Hou J, et al. Among authors: roy mj. Sci Signal. 2022 Feb 22;15(722):eabj3554. doi: 10.1126/scisignal.abj3554. Epub 2022 Feb 22. Sci Signal. 2022. PMID: 35192416

6

Production and purification of the PEAK pseudokinases for structural and functional studies.

Patel O, Surudoi M, Dai W, Hardy JM, Roy MJ, Lucet IS. Patel O, et al. Among authors: roy mj. Methods Enzymol. 2022;667:1-35. doi: 10.1016/bs.mie.2022.03.022. Epub 2022 Apr 25. Methods Enzymol. 2022. PMID: 35525538

7

A selective and orally bioavailable VHL-recruiting PROTAC achieves SMARCA2 degradation in vivo.

Kofink C, Trainor N, Mair B, Wöhrle S, Wurm M, Mischerikow N, Roy MJ, Bader G, Greb P, Garavel G, Diers E, McLennan R, Whitworth C, Vetma V, Rumpel K, Scharnweber M, Fuchs JE, Gerstberger T, Cui Y, Gremel G, Chetta P, Hopf S, Budano N, Rinnenthal J, Gmaschitz G, Mayer M, Koegl M, Ciulli A, Weinstabl H, Farnaby W. Kofink C, et al. Among authors: roy mj. Nat Commun. 2022 Oct 10;13(1):5969. doi: 10.1038/s41467-022-33430-6. Nat Commun. 2022. PMID: 36216795 Free PMC article.

8

BAK core dimers bind lipids and can be bridged by them.

Cowan AD, Smith NA, Sandow JJ, Kapp EA, Rustam YH, Murphy JM, Brouwer JM, Bernardini JP, Roy MJ, Wardak AZ, Tan IK, Webb AI, Gulbis JM, Smith BJ, Reid GE, Dewson G, Colman PM, Czabotar PE. Cowan AD, et al. Among authors: roy mj. Nat Struct Mol Biol. 2020 Nov;27(11):1024-1031. doi: 10.1038/s41594-020-0494-5. Epub 2020 Sep 14. Nat Struct Mol Biol. 2020. PMID: 32929280

9

Structure-Guided Development of Potent Benzoylurea Inhibitors of BCL-X_L and BCL-2.

Roy MJ, Vom A, Okamoto T, Smith BJ, Birkinshaw RW, Yang H, Abdo H, White CA, Segal D, Huang DCS, Baell JB, Colman PM, Czabotar PE, Lessene G. Roy MJ, et al. J Med Chem. 2021 May 13;64(9):5447-5469. doi: 10.1021/acs.jmedchem.0c01771. Epub 2021 Apr 27. J Med Chem. 2021. PMID: 33904752

10

Sequence differences between BAX and BAK core domains manifest as differences in their interactions with lipids.

Miller MS, Cowan AD, Brouwer JM, Smyth ST, Peng L, Wardak AZ, Uren RT, Luo C, Roy MJ, Shah S, Tan Z, Reid GE, Colman PM, Czabotar PE. Miller MS, et al. Among authors: roy mj. FEBS J. 2024 Jun;291(11):2335-2353. doi: 10.1111/febs.17031. Epub 2024 Jan 19. FEBS J. 2024. PMID: 38088212

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