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Generation of host-directed and virus-specific antivirals using targeted protein degradation promoted by small molecules and viral RNA mimics.
Zhao N, Ho JSY, Meng F, Zheng S, Kurland AP, Tian L, Rea-Moreno M, Song X, Seo JS, Kaniskan HÜ, Te Velthuis AJW, Tortorella D, Chen YW, Johnson JR, Jin J, Marazzi I. Zhao N, et al. Among authors: te velthuis ajw. Cell Host Microbe. 2023 Jul 12;31(7):1154-1169.e10. doi: 10.1016/j.chom.2023.05.030. Epub 2023 Jun 5. Cell Host Microbe. 2023. PMID: 37339625 Free PMC article.
Probing the functional constraints of influenza A virus NEP by deep mutational scanning.
Teo QW, Wang Y, Lv H, Oade MS, Mao KJ, Tan TJC, Huan YW, Rivera-Cardona J, Shao EK, Choi D, Wang C, Dargani ZT, Brooke CB, Te Velthuis AJW, Wu NC. Teo QW, et al. Among authors: te velthuis ajw. Cell Rep. 2025 Jan 14;44(1):115196. doi: 10.1016/j.celrep.2024.115196. Online ahead of print. Cell Rep. 2025. PMID: 39817904 Free article.
Influenza A virus transcription generates capped cRNAs that activate RIG-I.
Elshina E, Pitre E, Mendes M, Schweibenz B, Fan RLY, French H, Park JW, Wang W, Poon LLM, Marcotrigiano J, Russell AB, Te Velthuis AJW. Elshina E, et al. Among authors: te velthuis ajw. bioRxiv [Preprint]. 2024 Dec 3:2024.11.12.623191. doi: 10.1101/2024.11.12.623191. bioRxiv. 2024. PMID: 39605425 Free PMC article. Preprint.
Quantification of influenza virus mini viral RNAs using Cas13.
Lamb CH, Pitré EM, Ajufo S, Rigby CV, Bisht K, Oade MS, Jalal H, Myhrvold C, Te Velthuis AJW. Lamb CH, et al. Among authors: te velthuis ajw. RNA. 2024 Dec 16;31(1):126-138. doi: 10.1261/rna.080174.124. RNA. 2024. PMID: 39419543 Free PMC article.
Long-term evolution of human seasonal influenza virus A(H3N2) is associated with an increase in polymerase complex activity.
Vigeveno RM, Han AX, de Vries RP, Parker E, de Haan K, van Leeuwen S, Hulme KD, Lauring AS, Te Velthuis AJW, Boons GJ, Fouchier RAM, Russell CA, de Jong MD, Eggink D. Vigeveno RM, et al. Among authors: te velthuis ajw. Virus Evol. 2024 May 4;10(1):veae030. doi: 10.1093/ve/veae030. eCollection 2024. Virus Evol. 2024. PMID: 38808037 Free PMC article.
RNA Polymerase Inhibitor Enisamium for Treatment of Moderate COVID-19 Patients: A Randomized, Placebo-Controlled, Multicenter, Double-Blind Phase 3 Clinical Trial.
Holubovska O, Babich P, Mironenko A, Milde J, Lebed Y, Stammer H, Mueller L, Te Velthuis AJW, Margitich V, Goy A. Holubovska O, et al. Among authors: te velthuis ajw. Adv Respir Med. 2024 May 6;92(3):202-217. doi: 10.3390/arm92030021. Adv Respir Med. 2024. PMID: 38804439 Free PMC article. Clinical Trial.
Transient RNA structures underlie highly pathogenic avian influenza virus genesis.
Funk M, Spronken MI, Bestebroer TM, de Bruin ACM, Gultyaev AP, Fouchier RAM, Te Velthuis AJW, Richard M. Funk M, et al. Among authors: te velthuis ajw. bioRxiv [Preprint]. 2024 Jan 11:2024.01.11.574333. doi: 10.1101/2024.01.11.574333. bioRxiv. 2024. PMID: 38370829 Free PMC article. Preprint.
71 results