Liu L - Search Results

1

Identification of a Discrete Diglucuronide of GDC-0810 in Human Plasma after Oral Administration.

Zhang C, Su D, Choo EF, Liu L, Bobba S, Jorski JD, Ho Q, Wang J, Kenny JR, Khojasteh SC, Zhang D. Zhang C, et al. Among authors: liu l. Drug Metab Dispos. 2023 Oct;51(10):1284-1294. doi: 10.1124/dmd.122.001071. Epub 2023 Jun 22. Drug Metab Dispos. 2023. PMID: 37349116

2

Significant species difference in amide hydrolysis of GDC-0834, a novel potent and selective Bruton's tyrosine kinase inhibitor.

Liu L, Halladay JS, Shin Y, Wong S, Coraggio M, La H, Baumgardner M, Le H, Gopaul S, Boggs J, Kuebler P, Davis JC Jr, Liao XC, Lubach JW, Deese A, Sowell CG, Currie KS, Young WB, Khojasteh SC, Hop CE, Wong H. Liu L, et al. Drug Metab Dispos. 2011 Oct;39(10):1840-9. doi: 10.1124/dmd.111.040840. Epub 2011 Jul 8. Drug Metab Dispos. 2011. PMID: 21742900

3

Investigations into the mechanisms of pyridine ring cleavage in vismodegib.

Khojasteh SC, Yue Q, Ma S, Castanedo G, Chen JZ, Lyssikatos J, Mulder T, Takahashi R, Ly J, Messick K, Jia W, Liu L, Hop CE, Wong H. Khojasteh SC, et al. Among authors: liu l. Drug Metab Dispos. 2014 Mar;42(3):343-51. doi: 10.1124/dmd.113.055715. Epub 2014 Jan 3. Drug Metab Dispos. 2014. PMID: 24389420

4

Discovery and Biological Profiling of Potent and Selective mTOR Inhibitor GDC-0349.

Pei Z, Blackwood E, Liu L, Malek S, Belvin M, Koehler MF, Ortwine DF, Chen H, Cohen F, Kenny JR, Bergeron P, Lau K, Ly C, Zhao X, Estrada AA, Truong T, Epler JA, Nonomiya J, Trinh L, Sideris S, Lesnick J, Bao L, Vijapurkar U, Mukadam S, Tay S, Deshmukh G, Chen YH, Ding X, Friedman LS, Lyssikatos JP. Pei Z, et al. Among authors: liu l. ACS Med Chem Lett. 2012 Nov 29;4(1):103-7. doi: 10.1021/ml3003132. eCollection 2013 Jan 10. ACS Med Chem Lett. 2012. PMID: 24900569 Free PMC article.

5

A novel reaction mediated by human aldehyde oxidase: amide hydrolysis of GDC-0834.

Sodhi JK, Wong S, Kirkpatrick DS, Liu L, Khojasteh SC, Hop CE, Barr JT, Jones JP, Halladay JS. Sodhi JK, et al. Among authors: liu l. Drug Metab Dispos. 2015 Jun;43(6):908-15. doi: 10.1124/dmd.114.061804. Epub 2015 Apr 6. Drug Metab Dispos. 2015. PMID: 25845827 Free PMC article.

6

Practical strategies when using a stable isotope labeled microtracer for absolute bioavailability assessment: A case study of a high oral dose clinical candidate GDC-0810.

Chen B, Lu P, Freeman D, Gao Y, Choo E, DeMent K, Savage S, Zhang K, Milanwoski D, Liu L, Dean B, Deng Y. Chen B, et al. Among authors: liu l. J Pharm Biomed Anal. 2018 May 30;154:116-122. doi: 10.1016/j.jpba.2018.02.050. Epub 2018 Feb 23. J Pharm Biomed Anal. 2018. PMID: 29549853

7

Effect of OATP1B1/1B3 Inhibitor GDC-0810 on the Pharmacokinetics of Pravastatin and Coproporphyrin I/III in Healthy Female Subjects.

Liu L, Cheeti S, Yoshida K, Choo E, Chen E, Chen B, Gates M, Singel S, Morley R, Ware J, Sahasranaman S. Liu L, et al. J Clin Pharmacol. 2018 Nov;58(11):1427-1435. doi: 10.1002/jcph.1261. Epub 2018 May 22. J Clin Pharmacol. 2018. PMID: 29786857

8

Assessment of OATP transporter-mediated drug-drug interaction using physiologically-based pharmacokinetic (PBPK) modeling - a case example.

Chen Y, Zhu R, Ma F, Mao J, Chen EC, Choo EF, Sahasranaman S, Liu L. Chen Y, et al. Among authors: liu l. Biopharm Drug Dispos. 2018 Nov;39(9):420-430. doi: 10.1002/bdd.2159. Epub 2018 Nov 20. Biopharm Drug Dispos. 2018. PMID: 30335192

9

GDC-0810 Pharmacokinetics and Transporter-Mediated Drug Interaction Evaluation with an Endogenous Biomarker in the First-in-Human, Dose Escalation Study.

Cheung KWK, Yoshida K, Cheeti S, Chen B, Morley R, Chan IT, Sahasranaman S, Liu L. Cheung KWK, et al. Among authors: liu l. Drug Metab Dispos. 2019 Sep;47(9):966-973. doi: 10.1124/dmd.119.087924. Epub 2019 Jul 2. Drug Metab Dispos. 2019. PMID: 31266752 Clinical Trial.

10

Validation and application of a liquid chromatography-tandem mass spectrometric method for the determination of GDC-0834 and its metabolite in human plasma using semi-automated 96-well protein precipitation.

Shin YG, Jones SA, Murakami SC, Liu L, Wong H, Buonarati MH, Hop CE. Shin YG, et al. Among authors: liu l. Biomed Chromatogr. 2012 Nov;26(11):1444-51. doi: 10.1002/bmc.2716. Epub 2012 Feb 7. Biomed Chromatogr. 2012. PMID: 22311651 Clinical Trial.

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