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Fully human monoclonal antibody targeting the cysteine-rich substrate-interacting region of ADAM17 on cancer cells.
Saha N, Lee SG, Brockmann EC, de la Cruz MJ, Goldgur Y, Mendoza RP, Stanchina E, Love TM, Marvald J, Xu Y, Xu K, Himanen JP, Lamminmäki U, Veach D, Nikolov DB. Saha N, et al. Among authors: himanen jp. Biomed Pharmacother. 2024 Nov;180:117605. doi: 10.1016/j.biopha.2024.117605. Epub 2024 Oct 25. Biomed Pharmacother. 2024. PMID: 39461016 Free article.
Integration of cancer-related genetic landscape of Eph receptors and ephrins with proteomics identifies a crosstalk between EPHB6 and EGFR.
Hanover G, Vizeacoumar FS, Banerjee SL, Nair R, Dahiya R, Osornio-Hernandez AI, Morales AM, Freywald T, Himanen JP, Toosi BM, Bisson N, Vizeacoumar FJ, Freywald A. Hanover G, et al. Among authors: himanen jp. Cell Rep. 2023 Jul 25;42(7):112670. doi: 10.1016/j.celrep.2023.112670. Epub 2023 Jun 30. Cell Rep. 2023. PMID: 37392382 Free article.
A Multipronged Unbiased Strategy Guides the Development of an Anti-EGFR/EPHA2-Bispecific Antibody for Combination Cancer Therapy.
El Zawily A, Vizeacoumar FS, Dahiya R, Banerjee SL, Bhanumathy KK, Elhasasna H, Hanover G, Sharpe JC, Sanchez MG, Greidanus P, Stacey RG, Moon KM, Alexandrov I, Himanen JP, Nikolov DB, Fonge H, White AP, Foster LJ, Wang B, Toosi BM, Bisson N, Mirzabekov TA, Vizeacoumar FJ, Freywald A. El Zawily A, et al. Among authors: himanen jp. Clin Cancer Res. 2023 Jul 14;29(14):2686-2701. doi: 10.1158/1078-0432.CCR-22-2535. Clin Cancer Res. 2023. PMID: 36976175 Free PMC article.
Ephrin-A1 and the sheddase ADAM12 are upregulated in COVID-19.
Mendoza R, Saha N, Momeni A, Gabutan E, Alawad M, Dehghani A, Diks J, Lin B, Wang D, Alshal M, Fyke W, Wang B, Himanen JP, Premsrirut P, Nikolov DB. Mendoza R, et al. Among authors: himanen jp. Heliyon. 2021 Jun;7(6):e07200. doi: 10.1016/j.heliyon.2021.e07200. Epub 2021 May 31. Heliyon. 2021. PMID: 34095559 Free PMC article.
Structure of the EphB6 receptor ectodomain.
Mason EO, Goldgur Y, Robev D, Freywald A, Nikolov DB, Himanen JP. Mason EO, et al. Among authors: himanen jp. PLoS One. 2021 Mar 26;16(3):e0247335. doi: 10.1371/journal.pone.0247335. eCollection 2021. PLoS One. 2021. PMID: 33770085 Free PMC article.
Therapeutic potential of targeting the Eph/ephrin signaling complex.
Saha N, Robev D, Mason EO, Himanen JP, Nikolov DB. Saha N, et al. Among authors: himanen jp. Int J Biochem Cell Biol. 2018 Dec;105:123-133. doi: 10.1016/j.biocel.2018.10.006. Epub 2018 Oct 19. Int J Biochem Cell Biol. 2018. PMID: 30343150 Free PMC article. Review.
Binding of EphrinA5 to RET receptor tyrosine kinase: An in vitro study.
Liu Y, Kaljunen H, Pavić A, Saarenpää T, Himanen JP, Nikolov DB, Goldman A. Liu Y, et al. Among authors: himanen jp. PLoS One. 2018 Jun 11;13(6):e0198291. doi: 10.1371/journal.pone.0198291. eCollection 2018. PLoS One. 2018. PMID: 29889908 Free PMC article.
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