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Page 1
Seizure reduction in TSC2-mutant mouse model by an mTOR catalytic inhibitor.
Dhamne SC, Modi ME, Gray A, Bonazzi S, Craig L, Bainbridge E, Lalani L, Super CE, Schaeffer S, Capre K, Lubicka D, Liang G, Burdette D, McTighe SM, Gurnani S, Vermudez SAD, Curtis D, Wilson CJ, Hameed MQ, D'Amore A, Rotenberg A, Sahin M. Dhamne SC, et al. Among authors: capre k. Ann Clin Transl Neurol. 2023 Oct;10(10):1790-1801. doi: 10.1002/acn3.51868. Epub 2023 Aug 6. Ann Clin Transl Neurol. 2023. PMID: 37545094 Free PMC article.
Identification of Brain-Penetrant ATP-Competitive mTOR Inhibitors for CNS Syndromes.
Bonazzi S, Gray A, Thomsen NM, Biag J, Labbe-Giguere N, Keaney EP, Malik HA, Sun Y, Nunez J, Karki RG, Knapp M, Elling R, Fuller J, Pardee G, Craig L, Capre K, Salas S, Gorde A, Liang G, Lubicka D, McTighe SM, Goold C, Liu S, Deng L, Hong J, Fekete A, Stadelmann P, Frieauff W, Elhajouji A, Bauer D, Lerchner A, Radetich B, Furet P, Piizzi G, Burdette D, Wilson CJ, Peukert S, Hamann LG, Murphy LO, Curtis D. Bonazzi S, et al. Among authors: capre k. J Med Chem. 2023 Jul 13;66(13):9095-9119. doi: 10.1021/acs.jmedchem.3c00705. Epub 2023 Jul 3. J Med Chem. 2023. PMID: 37399505
Genome-wide CRISPR screen identifies protein pathways modulating tau protein levels in neurons.
Sanchez CG, Acker CM, Gray A, Varadarajan M, Song C, Cochran NR, Paula S, Lindeman A, An S, McAllister G, Alford J, Reece-Hoyes J, Russ C, Craig L, Capre K, Doherty C, Hoffman GR, Luchansky SJ, Polydoro M, Dolmetsch R, Elwood F. Sanchez CG, et al. Among authors: capre k. Commun Biol. 2021 Jun 14;4(1):736. doi: 10.1038/s42003-021-02272-1. Commun Biol. 2021. PMID: 34127790 Free PMC article.