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Dual Piperidine-Based Histamine H3 and Sigma-1 Receptor Ligands in the Treatment of Nociceptive and Neuropathic Pain.
Szczepańska K, Karcz T, Dichiara M, Mogilski S, Kalinowska-Tłuścik J, Pilarski B, Leniak A, Pietruś W, Podlewska S, Popiołek-Barczyk K, Humphrys LJ, Ruiz-Cantero MC, Reiner-Link D, Leitzbach L, Łażewska D, Pockes S, Górka M, Zmysłowski A, Calmels T, Cobos EJ, Marrazzo A, Stark H, Bojarski AJ, Amata E, Kieć-Kononowicz K. Szczepańska K, et al. Among authors: humphrys lj. J Med Chem. 2023 Jul 27;66(14):9658-9683. doi: 10.1021/acs.jmedchem.3c00430. Epub 2023 Jul 7. J Med Chem. 2023. PMID: 37418295 Free PMC article.
Clonidine stimulates force of contraction via histamine H2 receptors in the human atrium.
Neumann J, Pockes S, Humphrys LJ, Mönnich D, Forster L, Kirchhefer U, Hofmann B, Gergs U. Neumann J, et al. Among authors: humphrys lj. Naunyn Schmiedebergs Arch Pharmacol. 2024 Jan;397(1):617-626. doi: 10.1007/s00210-023-02635-x. Epub 2023 Jul 25. Naunyn Schmiedebergs Arch Pharmacol. 2024. PMID: 37490122 Free PMC article.
Ergometrine stimulates histamine H2 receptors in the isolated human atrium.
Jacob H, Braekow P, Hofmann B, Kirchhefer U, Forster L, Mönnich D, Humphrys LJ, Pockes S, Neumann J, Gergs U. Jacob H, et al. Among authors: humphrys lj. Naunyn Schmiedebergs Arch Pharmacol. 2023 Dec;396(12):3809-3822. doi: 10.1007/s00210-023-02573-8. Epub 2023 Jun 24. Naunyn Schmiedebergs Arch Pharmacol. 2023. PMID: 37354215 Free PMC article.
Guanidine Derivative ADS1017, a Potent Histamine H3 Receptor Antagonist with Promising Analgesic Activity and Satisfactory Safety Profile.
Karcz T, Szczepańska K, Mogilski S, Moroz A, Olejarz-Maciej A, Humphrys LJ, Pockes S, Siwek A, Dubiel K, Staszewski M, Calmels T, Waczyński K, Kieć-Kononowicz K. Karcz T, et al. Among authors: humphrys lj. ACS Chem Neurosci. 2024 Dec 18;15(24):4441-4457. doi: 10.1021/acschemneuro.4c00480. Epub 2024 Dec 9. ACS Chem Neurosci. 2024. PMID: 39652796
The novel adrenergic agonist ATR-127 targets skeletal muscle and brown adipose tissue to tackle diabesity and steatohepatitis.
Talamonti E, Davegardh J, Kalinovich A, van Beek SMM, Dehvari N, Halleskog C, Bokhari HM, Hutchinson DS, Ham S, Humphrys LJ, Dijon NC, Motso A, Sandstrom A, Zacharewicz E, Mutule I, Suna E, Spura J, Ditrychova K, Stoddart LA, Holliday ND, Wright SC, Lauschke VM, Nielsen S, Scheele C, Cheesman E, Hoeks J, Molenaar P, Summers RJ, Pelcman B, Yakala GK, Bengtsson T. Talamonti E, et al. Among authors: humphrys lj. Mol Metab. 2024 Jul;85:101931. doi: 10.1016/j.molmet.2024.101931. Epub 2024 May 17. Mol Metab. 2024. PMID: 38796310 Free PMC article.
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