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Page 1
Haploinsufficiency of lysosomal enzyme genes in Alzheimer's disease.
Benitez BA, Wallace CE, Patel M, Nykanen NP, Yuede CM, Eaton SL, Pottier C, Cetin A, Johnson M, Bevan MT, Gardiner WD, Edwards HM, Doherty BM, Harrigan RT, Kurian D, Wishart TM, Smith C, Cirrito JR, Sands MS. Benitez BA, et al. Among authors: nykanen np. bioRxiv [Preprint]. 2024 Nov 18:2024.11.16.623962. doi: 10.1101/2024.11.16.623962. bioRxiv. 2024. PMID: 39605615 Free PMC article. Preprint.
Proteo-genomics of soluble TREM2 in cerebrospinal fluid provides novel insights and identifies novel modulators for Alzheimer's disease.
Wang L, Nykänen NP, Western D, Gorijala P, Timsina J, Li F, Wang Z, Ali M, Yang C, Liu M, Brock W, Marquié M, Boada M, Alvarez I, Aguilar M, Pastor P, Ruiz A, Puerta R, Orellana A, Rutledge J, Oh H, Greicius MD, Le Guen Y, Perrin RJ, Wyss-Coray T, Jefferson A, Hohman TJ, Graff-Radford N, Mori H, Goate A, Levin J, Sung YJ, Cruchaga C. Wang L, et al. Among authors: nykanen np. Mol Neurodegener. 2024 Jan 3;19(1):1. doi: 10.1186/s13024-023-00687-4. Mol Neurodegener. 2024. PMID: 38172904 Free PMC article.
Proteome wide association studies of LRRK2 variants identify novel causal and druggable proteins for Parkinson's disease.
Phillips B, Western D, Wang L, Timsina J, Sun Y, Gorijala P, Yang C, Do A, Nykänen NP, Alvarez I, Aguilar M, Pastor P, Morris JC, Schindler SE, Fagan AM, Puerta R, García-González P, de Rojas I, Marquié M, Boada M, Ruiz A, Perlmutter JS; Dominantly Inherited Alzheimer Network (DIAN) Consortia; Ibanez L, Perrin RJ, Sung YJ, Cruchaga C. Phillips B, et al. Among authors: nykanen np. NPJ Parkinsons Dis. 2023 Jul 8;9(1):107. doi: 10.1038/s41531-023-00555-4. NPJ Parkinsons Dis. 2023. PMID: 37422510 Free PMC article.
Alpha-synuclein fragments trigger distinct aggregation pathways.
Chakroun T, Evsyukov V, Nykänen NP, Höllerhage M, Schmidt A, Kamp F, Ruf VC, Wurst W, Rösler TW, Höglinger GU. Chakroun T, et al. Among authors: nykanen np. Cell Death Dis. 2020 Feb 3;11(2):84. doi: 10.1038/s41419-020-2285-7. Cell Death Dis. 2020. PMID: 32015326 Free PMC article.
Four-repeat tauopathies.
Rösler TW, Tayaranian Marvian A, Brendel M, Nykänen NP, Höllerhage M, Schwarz SC, Hopfner F, Koeglsperger T, Respondek G, Schweyer K, Levin J, Villemagne VL, Barthel H, Sabri O, Müller U, Meissner WG, Kovacs GG, Höglinger GU. Rösler TW, et al. Among authors: nykanen np. Prog Neurobiol. 2019 Sep;180:101644. doi: 10.1016/j.pneurobio.2019.101644. Epub 2019 Jun 22. Prog Neurobiol. 2019. PMID: 31238088 Review.
FRMD4A-cytohesin signaling modulates the cellular release of tau.
Yan X, Nykänen NP, Brunello CA, Haapasalo A, Hiltunen M, Uronen RL, Huttunen HJ. Yan X, et al. Among authors: nykanen np. J Cell Sci. 2016 May 15;129(10):2003-15. doi: 10.1242/jcs.180745. Epub 2016 Apr 4. J Cell Sci. 2016. PMID: 27044754
Transcriptomics and mechanistic elucidation of Alzheimer's disease risk genes in the brain and in vitro models.
Martiskainen H, Viswanathan J, Nykänen NP, Kurki M, Helisalmi S, Natunen T, Sarajärvi T, Kurkinen KM, Pursiheimo JP, Rauramaa T, Alafuzoff I, Jääskeläinen JE, Leinonen V, Soininen H, Haapasalo A, Huttunen HJ, Hiltunen M. Martiskainen H, et al. Among authors: nykanen np. Neurobiol Aging. 2015 Feb;36(2):1221.e15-28. doi: 10.1016/j.neurobiolaging.2014.09.003. Epub 2014 Sep 6. Neurobiol Aging. 2015. PMID: 25281018
12 results