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Page 1
Structural basis for C-degron selectivity across KLHDCX family E3 ubiquitin ligases.
Scott DC, Chittori S, Purser N, King MT, Maiwald SA, Churion K, Nourse A, Lee C, Paulo JA, Miller DJ, Elledge SJ, Harper JW, Kleiger G, Schulman BA. Scott DC, et al. Among authors: harper jw. Nat Commun. 2024 Nov 15;15(1):9899. doi: 10.1038/s41467-024-54126-z. Nat Commun. 2024. PMID: 39548056 Free PMC article.
IRGQ-mediated autophagy in MHC class I quality control promotes tumor immune evasion.
Herhaus L, Gestal-Mato U, Eapen VV, Mačinković I, Bailey HJ, Prieto-Garcia C, Misra M, Jacomin AC, Ammanath AV, Bagarić I, Michaelis J, Vollrath J, Bhaskara RM, Bündgen G, Covarrubias-Pinto A, Husnjak K, Zöller J, Gikandi A, Ribičić S, Bopp T, van der Heden van Noort GJ, Langer JD, Weigert A, Harper JW, Mancias JD, Dikic I. Herhaus L, et al. Among authors: harper jw. Cell. 2024 Oct 21:S0092-8674(24)01148-6. doi: 10.1016/j.cell.2024.09.048. Online ahead of print. Cell. 2024. PMID: 39481378 Free article.
Principles of paralog-specific targeted protein degradation engaging the C-degron E3 KLHDC2.
Scott DC, Dharuman S, Griffith E, Chai SC, Ronnebaum J, King MT, Tangallapally R, Lee C, Gee CT, Yang L, Li Y, Loudon VC, Lee HW, Ochoada J, Miller DJ, Jayasinghe T, Paulo JA, Elledge SJ, Harper JW, Chen T, Lee RE, Schulman BA. Scott DC, et al. Among authors: harper jw. Nat Commun. 2024 Oct 12;15(1):8829. doi: 10.1038/s41467-024-52966-3. Nat Commun. 2024. PMID: 39396041 Free PMC article.
Pharmacological PINK1 activation ameliorates Pathology in Parkinson's Disease models.
Hertz N, Chin R, Rakhit R, Ditsworth D, Wang C, Bartholomeus J, Liu S, Mody A, Laihsu A, Eastes A, Tai C, Kim R, Li J, Khasnavis S, Rafalski V, Heerendeen D, Garda V, Phung J, de Roulet D, Ordureau A, Harper JW, Johnstone S, Stöhr J. Hertz N, et al. Among authors: harper jw. Res Sq [Preprint]. 2024 May 10:rs.3.rs-4356493. doi: 10.21203/rs.3.rs-4356493/v1. Res Sq. 2024. PMID: 38765977 Free PMC article. Preprint.
Visualizing chaperone-mediated multistep assembly of the human 20S proteasome.
Adolf F, Du J, Goodall EA, Walsh RM Jr, Rawson S, von Gronau S, Harper JW, Hanna J, Schulman BA. Adolf F, et al. Among authors: harper jw. Nat Struct Mol Biol. 2024 Aug;31(8):1176-1188. doi: 10.1038/s41594-024-01268-9. Epub 2024 Apr 10. Nat Struct Mol Biol. 2024. PMID: 38600324 Free PMC article.
Global cellular proteo-lipidomic profiling of diverse lysosomal storage disease mutants using nMOST.
Kraus F, He Y, Swarup S, Overmyer KA, Jiang Y, Brenner J, Capitanio C, Bieber A, Jen A, Nightingale NM, Anderson BJ, Lee C, Paulo JA, Smith IR, Plitzko JM, Gygi SP, Schulman BA, Wilfling F, Coon JJ, Harper JW. Kraus F, et al. Among authors: harper jw. bioRxiv [Preprint]. 2024 Oct 20:2024.03.26.586828. doi: 10.1101/2024.03.26.586828. bioRxiv. 2024. PMID: 38585873 Free PMC article. Preprint.
Combinatorial selective ER-phagy remodels the ER during neurogenesis.
Hoyer MJ, Capitanio C, Smith IR, Paoli JC, Bieber A, Jiang Y, Paulo JA, Gonzalez-Lozano MA, Baumeister W, Wilfling F, Schulman BA, Harper JW. Hoyer MJ, et al. Among authors: harper jw. Nat Cell Biol. 2024 Mar;26(3):378-392. doi: 10.1038/s41556-024-01356-4. Epub 2024 Mar 1. Nat Cell Biol. 2024. PMID: 38429475 Free PMC article.
357 results