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PP2A-based triple-strike therapy overcomes mitochondrial apoptosis resistance in brain cancer cells.
Denisova OV, Merisaari J, Huhtaniemi R, Qiao X, Yetukuri L, Jumppanen M, Kaur A, Pääkkönen M, von Schantz-Fant С, Ohlmeyer M, Wennerberg K, Kauko O, Koch R, Aittokallio T, Taipale M, Westermarck J. Denisova OV, et al. Among authors: kaur a. Mol Oncol. 2023 Sep;17(9):1803-1820. doi: 10.1002/1878-0261.13488. Epub 2023 Jul 26. Mol Oncol. 2023. PMID: 37458534 Free PMC article.
PP2A Inhibitor PME-1 Drives Kinase Inhibitor Resistance in Glioma Cells.
Kaur A, Denisova OV, Qiao X, Jumppanen M, Peuhu E, Ahmed SU, Raheem O, Haapasalo H, Eriksson J, Chalmers AJ, Laakkonen P, Westermarck J. Kaur A, et al. Cancer Res. 2016 Dec 1;76(23):7001-7011. doi: 10.1158/0008-5472.CAN-16-1134. Epub 2016 Sep 26. Cancer Res. 2016. PMID: 27671680
Development of actionable targets of multi-kinase inhibitors (AToMI) screening platform to dissect kinase targets of staurosporines in glioblastoma cells.
Denisova OV, Merisaari J, Kaur A, Yetukuri L, Jumppanen M, von Schantz-Fant C, Ohlmeyer M, Wennerberg K, Aittokallio T, Taipale M, Westermarck J. Denisova OV, et al. Among authors: kaur a. Sci Rep. 2022 Aug 13;12(1):13796. doi: 10.1038/s41598-022-18118-7. Sci Rep. 2022. PMID: 35963891 Free PMC article.
PP2A methylesterase PME-1 suppresses anoikis and is associated with therapy relapse of PTEN-deficient prostate cancers.
Aakula A, Isomursu A, Rupp C, Erickson A, Gupta N, Kauko O, Shah P, Padzik A, Pokharel YR, Kaur A, Li SP, Trotman L, Taimen P, Rannikko A, Lammerding J, Paatero I, Mirtti T, Ivaska J, Westermarck J. Aakula A, et al. Among authors: kaur a. Mol Oncol. 2023 Jun;17(6):1007-1023. doi: 10.1002/1878-0261.13353. Epub 2023 Apr 18. Mol Oncol. 2023. PMID: 36461911 Free PMC article.
Optimized design and analysis of preclinical intervention studies in vivo.
Laajala TD, Jumppanen M, Huhtaniemi R, Fey V, Kaur A, Knuuttila M, Aho E, Oksala R, Westermarck J, Mäkelä S, Poutanen M, Aittokallio T. Laajala TD, et al. Among authors: kaur a. Sci Rep. 2016 Aug 2;6:30723. doi: 10.1038/srep30723. Sci Rep. 2016. PMID: 27480578 Free PMC article.
2,572 results