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hERG stereoselective modulation by mexiletine-derived ureas: Molecular docking study, synthesis, and biological evaluation.
Milani G, Budriesi R, Tavazzani E, Cavalluzzi MM, Mattioli LB, Miniero DV, Delre P, Belviso BD, Denegri M, Cuocci C, Rotondo NP, De Palma A, Gualdani R, Caliandro R, Mangiatordi GF, Kumawat A, Camilloni C, Priori S, Lentini G. Milani G, et al. Among authors: de palma a. Arch Pharm (Weinheim). 2023 Oct;356(10):e2300116. doi: 10.1002/ardp.202300116. Epub 2023 Jul 17. Arch Pharm (Weinheim). 2023. PMID: 37460390 Free article.
Synthesis and toxicopharmacological evaluation of m-hydroxymexiletine, the first metabolite of mexiletine more potent than the parent compound on voltage-gated sodium channels.
Catalano A, Desaphy JF, Lentini G, Carocci A, Di Mola A, Bruno C, Carbonara R, De Palma A, Budriesi R, Ghelardini C, Perrone MG, Colabufo NA, Conte Camerino D, Franchini C. Catalano A, et al. Among authors: de palma a. J Med Chem. 2012 Feb 9;55(3):1418-22. doi: 10.1021/jm201197z. Epub 2012 Jan 31. J Med Chem. 2012. PMID: 22191686
Synthesis, antiarrhythmic activity, and toxicological evaluation of mexiletine analogues.
Roselli M, Carocci A, Budriesi R, Micucci M, Toma M, Di Cesare Mannelli L, Lovece A, Catalano A, Cavalluzzi MM, Bruno C, De Palma A, Contino M, Perrone MG, Colabufo NA, Chiarini A, Franchini C, Ghelardini C, Habtemariam S, Lentini G. Roselli M, et al. Among authors: de palma a. Eur J Med Chem. 2016 Oct 4;121:300-307. doi: 10.1016/j.ejmech.2016.05.046. Epub 2016 May 24. Eur J Med Chem. 2016. PMID: 27267000
Mannich base approach to 5-methoxyisatin 3-(4-isopropylphenyl)hydrazone: A water-soluble prodrug for a multitarget inhibition of cholinesterases, beta-amyloid fibrillization and oligomer-induced cytotoxicity.
Pisani L, De Palma A, Giangregorio N, Miniero DV, Pesce P, Nicolotti O, Campagna F, Altomare CD, Catto M. Pisani L, et al. Among authors: de palma a. Eur J Pharm Sci. 2017 Nov 15;109:381-388. doi: 10.1016/j.ejps.2017.08.004. Epub 2017 Aug 9. Eur J Pharm Sci. 2017. PMID: 28801274
Synthesis and Evaluation of Voltage-Gated Sodium Channel Blocking Pyrroline Derivatives Endowed with Both Antiarrhythmic and Antioxidant Activities.
Carocci A, Roselli M, Budriesi R, Micucci M, Desaphy JF, Altamura C, Cavalluzzi MM, Toma M, Passeri GI, Milani G, Lovece A, Catalano A, Bruno C, De Palma A, Corbo F, Franchini C, Habtemariam S, Lentini G. Carocci A, et al. Among authors: de palma a. ChemMedChem. 2021 Feb 4;16(3):578-588. doi: 10.1002/cmdc.202000692. Epub 2020 Oct 28. ChemMedChem. 2021. PMID: 33015979
Densely Functionalized 2-Methylideneazetidines: Evaluation as Antibacterials.
Petrillo G, Tavani C, Bianchi L, Benzi A, Cavalluzzi MM, Salvagno L, Quintieri L, De Palma A, Caputo L, Rosato A, Lentini G. Petrillo G, et al. Among authors: de palma a. Molecules. 2021 Jun 25;26(13):3891. doi: 10.3390/molecules26133891. Molecules. 2021. PMID: 34202191 Free PMC article.
376 results