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Discovery of evocalcet, a next-generation calcium-sensing receptor agonist for the treatment of hyperparathyroidism.
Miyazaki H, Ikeda Y, Sakurai O, Miyake T, Tsubota R, Okabe J, Kuroda M, Hisada Y, Yanagida T, Yoneda H, Tsukumo Y, Tokunaga S, Kawata T, Ohashi R, Fukuda H, Kojima K, Kannami A, Kifuji T, Sato N, Idei A, Iguchi T, Sakairi T, Moritani Y. Miyazaki H, et al. Among authors: kawata t. Bioorg Med Chem Lett. 2018 Jun 15;28(11):2055-2060. doi: 10.1016/j.bmcl.2018.04.055. Epub 2018 Apr 24. Bioorg Med Chem Lett. 2018. PMID: 29724589 Free article.
Development of evocalcet for unmet needs among calcimimetic agents.
Hamano N, Endo Y, Kawata T, Fukagawa M. Hamano N, et al. Among authors: kawata t. Expert Rev Endocrinol Metab. 2020 Sep;15(5):299-310. doi: 10.1080/17446651.2020.1780911. Epub 2020 Jun 18. Expert Rev Endocrinol Metab. 2020. PMID: 32552012 Review.
A novel calcimimetic agent, evocalcet (MT-4580/KHK7580), suppresses the parathyroid cell function with little effect on the gastrointestinal tract or CYP isozymes in vivo and in vitro.
Kawata T, Tokunaga S, Murai M, Masuda N, Haruyama W, Shoukei Y, Hisada Y, Yanagida T, Miyazaki H, Wada M, Akizawa T, Fukagawa M. Kawata T, et al. PLoS One. 2018 Apr 3;13(4):e0195316. doi: 10.1371/journal.pone.0195316. eCollection 2018. PLoS One. 2018. PMID: 29614098 Free PMC article.
813 results