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Page 1
Dynamic transcriptomic responses to divergent acute exercise stimuli in young adults.
Lavin KM, Graham ZA, McAdam JS, O'Bryan SM, Drummer D, Bell MB, Kelley CJ, Lixandrão ME, Peoples B, Tuggle SC, Seay RS, Van Keuren-Jensen K, Huentelman MJ, Pirrotte P, Reiman R, Alsop E, Hutchins E, Antone J, Bonfitto A, Meechoovet B, Palade J, Talboom JS, Sullivan A, Aban I, Peri K, Broderick TJ, Bamman MM. Lavin KM, et al. Physiol Genomics. 2023 Apr 1;55(4):194-212. doi: 10.1152/physiolgenomics.00144.2022. Epub 2023 Mar 20. Physiol Genomics. 2023. PMID: 36939205 Free PMC article. Clinical Trial.
The Foundational Data Initiative for Parkinson Disease: Enabling efficient translation from genetic maps to mechanism.
Bressan E, Reed X, Bansal V, Hutchins E, Cobb MM, Webb MG, Alsop E, Grenn FP, Illarionova A, Savytska N, Violich I, Broeer S, Fernandes N, Sivakumar R, Beilina A, Billingsley KJ, Berghausen J, Pantazis CB, Pitz V, Patel D, Daida K, Meechoovet B, Reiman R, Courtright-Lim A, Logemann A, Antone J, Barch M, Kitchen R, Li Y, Dalgard CL; American Genome Center; Rizzu P, Hernandez DG, Hjelm BE, Nalls M, Gibbs JR, Finkbeiner S, Cookson MR, Van Keuren-Jensen K, Craig DW, Singleton AB, Heutink P, Blauwendraat C. Bressan E, et al. Cell Genom. 2023 Feb 6;3(3):100261. doi: 10.1016/j.xgen.2023.100261. eCollection 2023 Mar 8. Cell Genom. 2023. PMID: 36950378 Free PMC article.
RNA sequencing of whole blood reveals early alterations in immune cells and gene expression in Parkinson's disease.
Craig DW, Hutchins E, Violich I, Alsop E, Gibbs JR, Levy S, Robison M, Prasad N, Foroud T, Crawford KL, Toga AW, Whitsett TG, Kim S, Casey B, Reimer A, Hutten SJ, Frasier M, Kern F, Fehlman T, Keller A, Cookson MR, Van Keuren-Jensen K; Parkinson Progression Marker Initiative. Craig DW, et al. Nat Aging. 2021 Aug;1(8):734-747. doi: 10.1038/s43587-021-00088-6. Epub 2021 Aug 5. Nat Aging. 2021. PMID: 37117765
Deep sequencing of sncRNAs reveals hallmarks and regulatory modules of the transcriptome during Parkinson's disease progression.
Kern F, Fehlmann T, Violich I, Alsop E, Hutchins E, Kahraman M, Grammes NL, Guimarães P, Backes C, Poston KL, Casey B, Balling R, Geffers L, Krüger R, Galasko D, Mollenhauer B, Meese E, Wyss-Coray T, Craig DW, Van Keuren-Jensen K, Keller A. Kern F, et al. Nat Aging. 2021 Mar;1(3):309-322. doi: 10.1038/s43587-021-00042-6. Epub 2021 Mar 15. Nat Aging. 2021. PMID: 37118411
exRNA-eCLIP intersection analysis reveals a map of extracellular RNA binding proteins and associated RNAs across major human biofluids and carriers.
LaPlante EL, Stürchler A, Fullem R, Chen D, Starner AC, Esquivel E, Alsop E, Jackson AR, Ghiran I, Pereira G, Rozowsky J, Chang J, Gerstein MB, Alexander RP, Roth ME, Franklin JL, Coffey RJ, Raffai RL, Mansuy IM, Stavrakis S, deMello AJ, Laurent LC, Wang YT, Tsai CF, Liu T, Jones J, Van Keuren-Jensen K, Van Nostrand E, Mateescu B, Milosavljevic A. LaPlante EL, et al. Cell Genom. 2023 Apr 20;3(5):100303. doi: 10.1016/j.xgen.2023.100303. eCollection 2023 May 10. Cell Genom. 2023. PMID: 37228754 Free PMC article.
Moderate intrinsic phenotypic alterations in C9orf72 ALS/FTD iPSC-microglia despite the presence of C9orf72 pathological features.
Lorenzini I, Alsop E, Levy J, Gittings LM, Lall D, Rabichow BE, Moore S, Pevey R, Bustos LM, Burciu C, Bhatia D, Singer M, Saul J, McQuade A, Tzioras M, Mota TA, Logemann A, Rose J, Almeida S, Gao FB, Marks M, Donnelly CJ, Hutchins E, Hung ST, Ichida J, Bowser R, Spires-Jones T, Blurton-Jones M, Gendron TF, Baloh RH, Van Keuren-Jensen K, Sattler R. Lorenzini I, et al. Front Cell Neurosci. 2023 Jun 6;17:1179796. doi: 10.3389/fncel.2023.1179796. eCollection 2023. Front Cell Neurosci. 2023. PMID: 37346371 Free PMC article.
Modelling TDP-43 proteinopathy in Drosophila uncovers shared and neuron-specific targets across ALS and FTD relevant circuits.
Godfrey RK, Alsop E, Bjork RT, Chauhan BS, Ruvalcaba HC, Antone J, Gittings LM, Michael AF, Williams C, Hala'ufia G, Blythe AD, Hall M, Sattler R, Van Keuren-Jensen K, Zarnescu DC. Godfrey RK, et al. Acta Neuropathol Commun. 2023 Oct 20;11(1):168. doi: 10.1186/s40478-023-01656-0. Acta Neuropathol Commun. 2023. PMID: 37864255 Free PMC article.
A public resource of single cell transcriptomes and multiscale networks from persons with and without Alzheimer's disease.
Wang Q, Antone J, Alsop E, Reiman R, Funk C, Bendl J, Dudley JT, Liang WS, Karr TL, Roussos P, Bennett DA, De Jager PL, Serrano GE, Beach TG, Keuren-Jensen KV, Mastroeni D, Reiman EM, Readhead BP. Wang Q, et al. bioRxiv [Preprint]. 2023 Oct 24:2023.10.20.563319. doi: 10.1101/2023.10.20.563319. bioRxiv. 2023. Update in: Nat Commun. 2024 Jul 10;15(1):5815. doi: 10.1038/s41467-024-49790-0 PMID: 37961404 Free PMC article. Updated. Preprint.
Biological basis of extensive pleiotropy between blood traits and cancer risk.
Pardo-Cea MA, Farré X, Esteve A, Palade J, Espín R, Mateo F, Alsop E, Alorda M, Blay N, Baiges A, Shabbir A, Comellas F, Gómez A, Arnan M, Teulé A, Salinas M, Berrocal L, Brunet J, Rofes P, Lázaro C, Conesa M, Rojas JJ, Velten L, Fendler W, Smyczynska U, Chowdhury D, Zeng Y, He HH, Li R, Van Keuren-Jensen K, de Cid R, Pujana MA. Pardo-Cea MA, et al. Genome Med. 2024 Feb 2;16(1):21. doi: 10.1186/s13073-024-01294-8. Genome Med. 2024. PMID: 38308367 Free PMC article.
26 results