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343 results

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Page 1
Determination of Ligand-Binding Affinity (Kd) Using Transverse Relaxation Rate (R2) in the Ligand-Observed 1H NMR Experiment and Applications to Fragment-Based Drug Discovery.
Liu M, Mirza A, McAndrew PC, Thapaliya A, Pierrat OA, Stubbs M, Hahner T, Chessum NEA, Innocenti P, Caldwell J, Cheeseman MD, Bellenie BR, van Montfort RLM, Newton GK, Burke R, Collins I, Hoelder S. Liu M, et al. Among authors: collins i. J Med Chem. 2023 Aug 10;66(15):10617-10627. doi: 10.1021/acs.jmedchem.3c00758. Epub 2023 Jul 19. J Med Chem. 2023. PMID: 37467168 Free PMC article.
iTAG an optimized IMiD-induced degron for targeted protein degradation in human and murine cells.
Bouguenina H, Nicolaou S, Le Bihan YV, Bowling EA, Calderon C, Caldwell JJ, Harrington B, Hayes A, McAndrew PC, Mitsopoulos C, Sialana FJ, Scarpino A, Stubbs M, Thapaliya A, Tyagi S, Wang HZ, Wood F, Burke R, Raynaud F, Choudhary J, van Montfort RLM, Sadok A, Westbrook TF, Collins I, Chopra R. Bouguenina H, et al. Among authors: collins i. iScience. 2023 Jun 7;26(7):107059. doi: 10.1016/j.isci.2023.107059. eCollection 2023 Jul 21. iScience. 2023. PMID: 37360684 Free PMC article.
A Degron Blocking Strategy Towards Improved CRL4CRBN Recruiting PROTAC Selectivity.
Bouguenina H, Scarpino A, O'Hanlon JA, Warne J, Wang HZ, Wah Hak LC, Sadok A, McAndrew PC, Stubbs M, Pierrat OA, Hahner T, Cabry MP, Le Bihan YV, Mitsopoulos C, Sialana FJ, Roumeliotis TI, Burke R, van Montfort RLM, Choudhari J, Chopra R, Caldwell JJ, Collins I. Bouguenina H, et al. Among authors: collins i. Chembiochem. 2023 Dec 1;24(23):e202300351. doi: 10.1002/cbic.202300351. Epub 2023 Oct 10. Chembiochem. 2023. PMID: 37418539
Erratum: iTAG an optimized IMiD-induced degron for targeted protein degradation in human and murine cells.
Bouguenina H, Nicolaou S, Bihan YL, Bowling EA, Calderon C, Caldwell JJ, Harrington B, Hayes A, McAndrew PC, Mitsopoulos C, Sialana FJ, Scarpino A, Stubbs M, Thapaliya A, Tyagi S, Wang HZ, Wood F, Burke R, Raynaud F, Choudhary J, van Montfort RLM, Sadok A, Westbrook TF, Collins I, Chopra R. Bouguenina H, et al. Among authors: collins i. iScience. 2024 Apr 14;27(5):109727. doi: 10.1016/j.isci.2024.109727. eCollection 2024 May 17. iScience. 2024. PMID: 38646177 Free PMC article.
Cost-effectiveness of viral load testing for transitioning antiretroviral therapy-experienced children to dolutegravir in South Africa: a modelling analysis.
Brenner IR, Flanagan CF, Penazzato M, Webb KA, Horsfall SB, Hyle EP, Abrams E, Bacha J, Neilan AM, Collins IJ, Desmonde S, Crichton S, Davies MA, Freedberg KA, Ciaranello AL. Brenner IR, et al. Among authors: collins ij. Lancet Glob Health. 2024 Dec;12(12):e2068-e2079. doi: 10.1016/S2214-109X(24)00381-4. Lancet Glob Health. 2024. PMID: 39577977 Free PMC article.
Large-scale multi-omic analysis identifies noncoding somatic driver mutations and nominates ZFP36L2 as a driver gene for pancreatic ductal adenocarcinoma.
Zhong J, O'Brien A, Patel M, Eiser D, Mobaraki M, Collins I, Wang L, Guo K, TruongVo T, Jermusyk A, O'Neill M, Dill CD, Wells AD, Leonard ME, Pippin JA, Grant SFA, Zhang T, Andresson T, Connelly KE, Shi J, Arda HE, Hoskins JW, Amundadottir LT. Zhong J, et al. Among authors: collins i. medRxiv [Preprint]. 2024 Sep 24:2024.09.22.24314165. doi: 10.1101/2024.09.22.24314165. medRxiv. 2024. PMID: 39371173 Free PMC article. Preprint.
Allelic effects on KLHL17 expression likely mediated by JunB/D underlie a PDAC GWAS signal at chr1p36.33.
Connelly KE, Hullin K, Abdolalizadeh E, Zhong J, Eiser D, O'Brien A, Collins I, Sudipto Das, Duncan G; Pancreatic Cancer Cohort Consortium; Pancreatic Cancer Case-Control Consortium; Chanock SJ, Stolzenberg-Solomon RZ, Klein AP, Wolpin BM, Hoskins JW, Andresson T, Smith JP, Amundadottir LT. Connelly KE, et al. Among authors: collins i. medRxiv [Preprint]. 2024 Sep 16:2024.09.16.24313748. doi: 10.1101/2024.09.16.24313748. medRxiv. 2024. PMID: 39371158 Free PMC article. Preprint.
343 results