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Danicamtiv Increases Myosin Recruitment and Alters Cross-Bridge Cycling in Cardiac Muscle.
Kooiker KB, Mohran S, Turner KL, Ma W, Martinson A, Flint G, Qi L, Gao C, Zheng Y, McMillen TS, Mandrycky C, Mahoney-Schaefer M, Freeman JC, Costales Arenas EG, Tu AY, Irving TC, Geeves MA, Tanner BCW, Regnier M, Davis J, Moussavi-Harami F. Kooiker KB, et al. Among authors: qi l. Circ Res. 2023 Aug 18;133(5):430-443. doi: 10.1161/CIRCRESAHA.123.322629. Epub 2023 Jul 20. Circ Res. 2023. PMID: 37470183 Free PMC article.
Cardiac myosin filaments are directly regulated by calcium.
Ma W, Nag S, Gong H, Qi L, Irving TC. Ma W, et al. Among authors: qi l. J Gen Physiol. 2022 Dec 5;154(12):e202213213. doi: 10.1085/jgp.202213213. Epub 2022 Nov 1. J Gen Physiol. 2022. PMID: 36327149 Free PMC article.
Danicamtiv increases myosin recruitment and alters the chemomechanical cross bridge cycle in cardiac muscle.
Kooiker KB, Mohran S, Turner KL, Ma W, Flint G, Qi L, Gao C, Zheng Y, McMillen TS, Mandrycky C, Martinson A, Mahoney-Schaefer M, Freeman JC, Costales Arenas EG, Tu AY, Irving TC, Geeves MA, Tanner BCW, Regnier M, Davis J, Moussavi-Harami F. Kooiker KB, et al. Among authors: qi l. bioRxiv [Preprint]. 2023 Feb 3:2023.01.31.526380. doi: 10.1101/2023.01.31.526380. bioRxiv. 2023. Update in: Circ Res. 2023 Aug 18;133(5):430-443. doi: 10.1161/CIRCRESAHA.123.322629 PMID: 36778318 Free PMC article. Updated. Preprint.
Myosin in autoinhibited off state(s), stabilized by mavacamten, can be recruited via inotropic effectors.
Ma W, Del Rio CL, Qi L, Prodanovic M, Mijailovich S, Zambataro C, Gong H, Shimkunas R, Gollapudi S, Nag S, Irving TC. Ma W, et al. Among authors: qi l. bioRxiv [Preprint]. 2023 Aug 28:2023.04.10.536292. doi: 10.1101/2023.04.10.536292. bioRxiv. 2023. Update in: Proc Natl Acad Sci U S A. 2024 Feb 20;121(8):e2314914121. doi: 10.1073/pnas.2314914121 PMID: 37090664 Free PMC article. Updated. Preprint.
Disruption of Z-Disc Function Promotes Mechanical Dysfunction in Human Myocardium: Evidence for a Dual Myofilament Modulatory Role by Alpha-Actinin 2.
Rodriguez Garcia M, Schmeckpeper J, Landim-Vieira M, Coscarella IL, Fang X, Ma W, Spran PA, Yuan S, Qi L, Kahmini AR, Shoemaker MB, Atkinson JB, Kekenes-Huskey PM, Irving TC, Chase PB, Knollmann BC, Pinto JR. Rodriguez Garcia M, et al. Among authors: qi l. Int J Mol Sci. 2023 Sep 26;24(19):14572. doi: 10.3390/ijms241914572. Int J Mol Sci. 2023. PMID: 37834023 Free PMC article.
5,692 results