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Distinct mechanisms act in concert to mediate cell cycle arrest.
Toettcher JE, Loewer A, Ostheimer GJ, Yaffe MB, Tidor B, Lahav G. Toettcher JE, et al. Among authors: ostheimer gj. Proc Natl Acad Sci U S A. 2009 Jan 20;106(3):785-90. doi: 10.1073/pnas.0806196106. Epub 2009 Jan 12. Proc Natl Acad Sci U S A. 2009. PMID: 19139404 Free PMC article.
A mitotic phosphorylation feedback network connects Cdk1, Plk1, 53BP1, and Chk2 to inactivate the G(2)/M DNA damage checkpoint.
van Vugt MA, Gardino AK, Linding R, Ostheimer GJ, Reinhardt HC, Ong SE, Tan CS, Miao H, Keezer SM, Li J, Pawson T, Lewis TA, Carr SA, Smerdon SJ, Brummelkamp TR, Yaffe MB. van Vugt MA, et al. Among authors: ostheimer gj. PLoS Biol. 2010 Jan 26;8(1):e1000287. doi: 10.1371/journal.pbio.1000287. PLoS Biol. 2010. PMID: 20126263 Free PMC article.
Systematic discovery of in vivo phosphorylation networks.
Linding R, Jensen LJ, Ostheimer GJ, van Vugt MA, Jørgensen C, Miron IM, Diella F, Colwill K, Taylor L, Elder K, Metalnikov P, Nguyen V, Pasculescu A, Jin J, Park JG, Samson LD, Woodgett JR, Russell RB, Bork P, Yaffe MB, Pawson T. Linding R, et al. Among authors: ostheimer gj. Cell. 2007 Jun 29;129(7):1415-26. doi: 10.1016/j.cell.2007.05.052. Epub 2007 Jun 14. Cell. 2007. PMID: 17570479 Free PMC article.
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