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594 results

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Page 1
Human gain-of-function variants in HNF1A confer protection from diabetes but independently increase hepatic secretion of atherogenic lipoproteins.
DeForest N, Kavitha B, Hu S, Isaac R, Krohn L, Wang M, Du X, De Arruda Saldanha C, Gylys J, Merli E, Abagyan R, Najmi L, Mohan V; Alnylam Human Genetics; AMP-T2D Consortium; Flannick J, Peloso GM, Gordts PLSM, Heinz S, Deaton AM, Khera AV, Olefsky J, Radha V, Majithia AR. DeForest N, et al. Among authors: olefsky j. Cell Genom. 2023 May 30;3(7):100339. doi: 10.1016/j.xgen.2023.100339. eCollection 2023 Jul 12. Cell Genom. 2023. PMID: 37492105 Free PMC article.
TM7SF3 controls TEAD1 splicing to prevent MASH-induced liver fibrosis.
Isaac R, Bandyopadhyay G, Rohm TV, Kang S, Wang J, Pokhrel N, Sakane S, Zapata R, Libster AM, Vinik Y, Berhan A, Kisseleva T, Borok Z, Zick Y, Telese F, Webster NJG, Olefsky JM. Isaac R, et al. Among authors: olefsky jm. Cell Metab. 2024 May 7;36(5):1030-1043.e7. doi: 10.1016/j.cmet.2024.04.003. Epub 2024 Apr 25. Cell Metab. 2024. PMID: 38670107
IL-22 resolves MASLD via enterocyte STAT3 restoration of diet-perturbed intestinal homeostasis.
Zhang P, Liu J, Lee A, Tsaur I, Ohira M, Duong V, Vo N, Watari K, Su H, Kim JY, Gu L, Zhu M, Shalapour S, Hosseini M, Bandyopadhyay G, Zeng S, Llorente C, Zhao HN, Lamichhane S, Mohan S, Dorrestein PC, Olefsky JM, Schnabl B, Soroosh P, Karin M. Zhang P, et al. Among authors: olefsky jm. Cell Metab. 2024 Oct 1;36(10):2341-2354.e6. doi: 10.1016/j.cmet.2024.08.012. Epub 2024 Sep 23. Cell Metab. 2024. PMID: 39317186 Free article.
Identification of Genetic Variation Influencing Metformin Response in a Multiancestry Genome-Wide Association Study in the Diabetes Prevention Program (DPP).
Li JH, Perry JA, Jablonski KA, Srinivasan S, Chen L, Todd JN, Harden M, Mercader JM, Pan Q, Dawed AY, Yee SW, Pearson ER, Giacomini KM, Giri A, Hung AM, Xiao S, Williams LK, Franks PW, Hanson RL, Kahn SE, Knowler WC, Pollin TI, Florez JC; Diabetes Prevention Program Research Group:. Li JH, et al. Diabetes. 2023 Aug 1;72(8):1161-1172. doi: 10.2337/db22-0702. Diabetes. 2023. PMID: 36525397 Free PMC article.
Exosome-Mediated Impact on Systemic Metabolism.
Cunha E Rocha K, Ying W, Olefsky JM. Cunha E Rocha K, et al. Among authors: olefsky jm. Annu Rev Physiol. 2024 Feb 12;86:225-253. doi: 10.1146/annurev-physiol-042222-024535. Annu Rev Physiol. 2024. PMID: 38345906 Free article. Review.
Lipid-associated macrophages' promotion of fibrosis resolution during MASH regression requires TREM2.
Ganguly S, Rosenthal SB, Ishizuka K, Troutman TD, Rohm TV, Khader N, Aleman-Muench G, Sano Y, Archilei S, Soroosh P, Olefsky JM, Feldstein AE, Kisseleva T, Loomba R, Glass CK, Brenner DA, Dhar D. Ganguly S, et al. Among authors: olefsky jm. Proc Natl Acad Sci U S A. 2024 Aug 27;121(35):e2405746121. doi: 10.1073/pnas.2405746121. Epub 2024 Aug 22. Proc Natl Acad Sci U S A. 2024. PMID: 39172787 Free PMC article.
Author Correction: Adipose tissue macrophages secrete small extracellular vesicles that mediate rosiglitazone-induced insulin sensitization.
Rohm TV, Castellani Gomes Dos Reis F, Isaac R, Murphy C, Cunha E Rocha K, Bandyopadhyay G, Gao H, Libster AM, Zapata RC, Lee YS, Ying W, Miciano C, Wang A, Olefsky JM. Rohm TV, et al. Among authors: olefsky jm. Nat Metab. 2024 Aug;6(8):1646. doi: 10.1038/s42255-024-01094-9. Nat Metab. 2024. PMID: 38969830 No abstract available.
Prevalence of Distal Symmetrical Polyneuropathy by Diabetes Prevention Program Treatment Group, Diabetes Status, Duration of Diabetes, and Cumulative Glycemic Exposure.
Lee CG, Ciarleglio A, Edelstein SL, Crandall JP, Dabelea D, Goldberg RB, Kahn SE, Knowler WC, Ma MT, White NH, Herman WH; Diabetes Prevention Program Research Group. Lee CG, et al. Diabetes Care. 2024 May 1;47(5):810-817. doi: 10.2337/dc23-2009. Diabetes Care. 2024. PMID: 38502874 Clinical Trial.
594 results