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Page 1
Structure-Guided Design and Synthesis of a Pyridazinone Series of Trypanosoma cruzi Proteasome Inhibitors.
Thomas MG, McGonagle K, Rowland P, Robinson DA, Dodd PG, Camino-Díaz I, Campbell L, Cantizani J, Castañeda P, Conn D, Craggs PD, Edwards D, Ferguson L, Fosberry A, Frame L, Goswami P, Hu X, Korczynska J, MacLean L, Martin J, Mutter N, Osuna-Cabello M, Paterson C, Peña I, Pinto EG, Pont C, Riley J, Shishikura Y, Simeons FRC, Stojanovski L, Thomas J, Wrobel K, Young RJ, Zmuda F, Zuccotto F, Read KD, Gilbert IH, Marco M, Miles TJ, Manzano P, De Rycker M. Thomas MG, et al. Among authors: manzano p. J Med Chem. 2023 Aug 10;66(15):10413-10431. doi: 10.1021/acs.jmedchem.3c00582. Epub 2023 Jul 28. J Med Chem. 2023. PMID: 37506194 Free PMC article.
Hit-to-Lead Optimization of Benzoxazepinoindazoles As Human African Trypanosomiasis Therapeutics.
Klug DM, Tschiegg L, Diaz R, Rojas-Barros D, Perez-Moreno G, Ceballos G, García-Hernández R, Martinez-Martinez MS, Manzano P, Ruiz LM, Caffrey CR, Gamarro F, Pacanowska DG, Ferrins L, Navarro M, Pollastri MP. Klug DM, et al. Among authors: manzano p. J Med Chem. 2020 Mar 12;63(5):2527-2546. doi: 10.1021/acs.jmedchem.9b01506. Epub 2019 Nov 20. J Med Chem. 2020. PMID: 31670951 Free PMC article.
Selectivity and Physicochemical Optimization of Repurposed Pyrazolo[1,5-b]pyridazines for the Treatment of Human African Trypanosomiasis.
Tear WF, Bag S, Diaz-Gonzalez R, Ceballos-Pérez G, Rojas-Barros DI, Cordon-Obras C, Pérez-Moreno G, García-Hernández R, Martinez-Martinez MS, Ruiz-Perez LM, Gamarro F, Gonzalez Pacanowska D, Caffrey CR, Ferrins L, Manzano P, Navarro M, Pollastri MP. Tear WF, et al. Among authors: manzano p. J Med Chem. 2020 Jan 23;63(2):756-783. doi: 10.1021/acs.jmedchem.9b01741. Epub 2020 Jan 8. J Med Chem. 2020. PMID: 31846577 Free PMC article.
Lead Optimization of 3,5-Disubstituted-7-Azaindoles for the Treatment of Human African Trypanosomiasis.
Klug DM, Mavrogiannaki EM, Forbes KC, Silva L, Diaz-Gonzalez R, Pérez-Moreno G, Ceballos-Pérez G, Garcia-Hernández R, Bosch-Navarrete C, Cordón-Obras C, Gómez-Liñán C, Saura A, Momper JD, Martinez-Martinez MS, Manzano P, Syed A, El-Sakkary N, Caffrey CR, Gamarro F, Ruiz-Perez LM, Gonzalez Pacanowska D, Ferrins L, Navarro M, Pollastri MP. Klug DM, et al. Among authors: manzano p. J Med Chem. 2021 Jul 8;64(13):9404-9430. doi: 10.1021/acs.jmedchem.1c00674. Epub 2021 Jun 22. J Med Chem. 2021. PMID: 34156862 Free PMC article.
Identification and development of a series of disubstituted piperazines for the treatment of Chagas disease.
McGonagle K, Tarver GJ, Cantizani J, Cotillo I, Dodd PG, Ferguson L, Gilbert IH, Marco M, Miles T, Naylor C, Osuna-Cabello M, Paterson C, Read KD, Pinto EG, Riley J, Scullion P, Shishikura Y, Simeons F, Stojanovski L, Svensen N, Thomas J, Wyatt PG, Manzano P, De Rycker M, Thomas MG. McGonagle K, et al. Among authors: manzano p. Eur J Med Chem. 2022 Aug 5;238:114421. doi: 10.1016/j.ejmech.2022.114421. Epub 2022 May 6. Eur J Med Chem. 2022. PMID: 35594652 Free PMC article.
Pharmacophore Identification and Structure-Activity Relationship Analysis of a Series of Substituted Azaindoles as Inhibitors of Trypanosoma brucei.
Ferrins L, Diaz R, Cordon-Obras C, Rojas-Barros D, Quotadamo A, Oehme DP, Ceballos-Pérez G, Swaminathan U, Pérez-Moreno G, Bosch-Navarrete C, García-Hernández R, Gomez-Liñan C, Saura A, Ruiz-Perez LM, Gamarro F, Martinez-Martinez MS, Manzano P, González-Pacanowska D, Navarro M, Pollastri MP. Ferrins L, et al. Among authors: manzano p. J Med Chem. 2024 Aug 22;67(16):13985-14006. doi: 10.1021/acs.jmedchem.4c00785. Epub 2024 Aug 13. J Med Chem. 2024. PMID: 39136694 Free PMC article.
Potent antimalarial 4-pyridones with improved physico-chemical properties.
Bueno JM, Manzano P, García MC, Chicharro J, Puente M, Lorenzo M, García A, Ferrer S, Gómez RM, Fraile MT, Lavandera JL, Fiandor JM, Vidal J, Herreros E, Gargallo-Viola D. Bueno JM, et al. Among authors: manzano p. Bioorg Med Chem Lett. 2011 Sep 15;21(18):5214-8. doi: 10.1016/j.bmcl.2011.07.044. Epub 2011 Jul 23. Bioorg Med Chem Lett. 2011. PMID: 21824778
An Invitation to Open Innovation in Malaria Drug Discovery: 47 Quality Starting Points from the TCAMS.
Calderón F, Barros D, Bueno JM, Coterón JM, Fernández E, Gamo FJ, Lavandera JL, León ML, Macdonald SJ, Mallo A, Manzano P, Porras E, Fiandor JM, Castro J. Calderón F, et al. Among authors: manzano p. ACS Med Chem Lett. 2011 Aug 3;2(10):741-6. doi: 10.1021/ml200135p. eCollection 2011 Oct 13. ACS Med Chem Lett. 2011. PMID: 24900261 Free PMC article.
99 results