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Patients with naproxen-induced liver injury display T-cell memory responses toward an oxidative (S)-O-desmethyl naproxen metabolite but not the acyl glucuronide.
Thomson P, Fragkas N, Kafu LM, Aithal GP, Lucena MI, Terracciano L, Meng X, Pirmohamed M, Brees D, Kullak-Ublick GA, Odermatt A, Hammond T, Kammüller M, Naisbitt DJ. Thomson P, et al. Among authors: brees d. Allergy. 2024 Jan;79(1):200-214. doi: 10.1111/all.15830. Epub 2023 Jul 29. Allergy. 2024. PMID: 37515456 Free PMC article.
Anti-brolucizumab immune response as one prerequisite for rare retinal vasculitis/retinal vascular occlusion adverse events.
Karle AC, Wrobel MB, Koepke S, Gutknecht M, Gottlieb S, Christen B, Rubic-Schneider T, Pruimboom-Brees I, Leber XC, Scharenberg M, Maciejewski B, Turner O, Saravanan C, Huet F, Littlewood-Evans A, Clemens A, Grosskreutz CL, Kearns JD, Mehan P, Schmouder RL, Sasseville V, Brees D. Karle AC, et al. Among authors: brees d. Sci Transl Med. 2023 Feb;15(681):eabq5241. doi: 10.1126/scitranslmed.abq5241. Epub 2023 Feb 1. Sci Transl Med. 2023. PMID: 36724238
A root cause analysis to identify the mechanistic drivers of immunogenicity against the anti-VEGF biotherapeutic brolucizumab.
Kearns JD, Wassmann P, Olgac U, Fichter M, Christen B, Rubic-Schneider T, Koepke S, Cochin de Billy B, Ledieu D, Andre C, Hawtin S, Fischer B, Moretti F, Hug C, Bepperling A, Brannetti B, Mendez-Garcia C, Littlewood-Evans A, Clemens A, Grosskreutz CL, Mehan P, Schmouder RL, Sasseville V, Brees D, Karle AC. Kearns JD, et al. Among authors: brees d. Sci Transl Med. 2023 Feb;15(681):eabq5068. doi: 10.1126/scitranslmed.abq5068. Epub 2023 Feb 1. Sci Transl Med. 2023. PMID: 36724241
The challenge to identify sensitive safety biomarkers of peripheral neurotoxicity in the rat: A collaborative effort across industry and academia (IMI NeuroDeRisk project).
Micheli L, Balayssac D, Busserolles J, Dalbos C, Prival L, Richard D, Quintana M, Di Cesare Mannelli L, Toti A, Ciampi C, Ghelardini C, Vlasakova K, Glaab WE, Hu Y, Loryan I, Perrault O, Slaoui M, Wuersch K, Johnson E, Frieauff W, Penraat K, Brees D, Dubost V, Theil D. Micheli L, et al. Among authors: brees d. Toxicology. 2025 Jan;510:153998. doi: 10.1016/j.tox.2024.153998. Epub 2024 Nov 17. Toxicology. 2025. PMID: 39551123 Free article.
Therapeutic antibody glycosylation impacts antigen recognition and immunogenicity.
Wolf B, Piksa M, Beley I, Patoux A, Besson T, Cordier V, Voedisch B, Schindler P, Stöllner D, Perrot L, von Gunten S, Brees D, Kammüller M. Wolf B, et al. Among authors: brees d. Immunology. 2022 Jul;166(3):380-407. doi: 10.1111/imm.13481. Epub 2022 May 4. Immunology. 2022. PMID: 35416297 Free article.
Effect of ofatumumab on pregnancy, parturition, and lactation in cynomolgus monkeys.
Bellot M, Luetjens CM, Bagger M, Horvath C, Sutter E, DeLise A, Brees D, Carballido JM, Pingili R, Ramanathan K, Kieseier BC, Hellwig K. Bellot M, et al. Among authors: brees d. Reprod Toxicol. 2022 Mar;108:28-34. doi: 10.1016/j.reprotox.2021.12.006. Epub 2021 Dec 21. Reprod Toxicol. 2022. PMID: 34942355 Free article.
The use of emerging safety biomarkers in nonclinical and clinical safety assessment - The current and future state: An IQ DruSafe industry survey.
Zabka TS, Burkhardt J, Reagan WJ, Gautier JC, Glaab WE, Guffroy M, Harding J, Brees D, McDuffie E, Ramaiah L, Schultze AE, Smith JD, Wolfreys A, Dalmas DA. Zabka TS, et al. Among authors: brees d. Regul Toxicol Pharmacol. 2021 Mar;120:104857. doi: 10.1016/j.yrtph.2020.104857. Epub 2020 Dec 31. Regul Toxicol Pharmacol. 2021. PMID: 33387566 Free article.
46 results