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Ulinastatin inhibits the metastasis of nasopharyngeal carcinoma by involving uPA/uPAR signaling.
Li CZ, Qiang YY, Liu ZJ, Zheng LS, Peng LX, Mei Y, Meng DF, Wei WW, Chen DW, Xu L, Lang YH, Xie P, Peng XS, Wang MD, Guo LL, Shu DT, Ding LY, Lin ST, Luo FF, Wang J, Li SS, Huang BJ, Chen JD, Qian CN. Li CZ, et al. Among authors: peng lx. Drug Dev Res. 2023 Nov;84(7):1468-1481. doi: 10.1002/ddr.22098. Epub 2023 Aug 3. Drug Dev Res. 2023. PMID: 37534761
Serglycin is a theranostic target in nasopharyngeal carcinoma that promotes metastasis.
Li XJ, Ong CK, Cao Y, Xiang YQ, Shao JY, Ooi A, Peng LX, Lu WH, Zhang Z, Petillo D, Qin L, Bao YN, Zheng FJ, Chia CS, Iyer NG, Kang TB, Zeng YX, Soo KC, Trent JM, Teh BT, Qian CN. Li XJ, et al. Among authors: peng lx. Cancer Res. 2011 Apr 15;71(8):3162-72. doi: 10.1158/0008-5472.CAN-10-3557. Epub 2011 Feb 2. Cancer Res. 2011. PMID: 21289131
As an independent unfavorable prognostic factor, IL-8 promotes metastasis of nasopharyngeal carcinoma through induction of epithelial-mesenchymal transition and activation of AKT signaling.
Li XJ, Peng LX, Shao JY, Lu WH, Zhang JX, Chen S, Chen ZY, Xiang YQ, Bao YN, Zheng FJ, Zeng MS, Kang TB, Zeng YX, Teh BT, Qian CN. Li XJ, et al. Among authors: peng lx. Carcinogenesis. 2012 Jul;33(7):1302-9. doi: 10.1093/carcin/bgs181. Epub 2012 May 18. Carcinogenesis. 2012. PMID: 22610073 Free PMC article.
Epstein-Barr Virus_Encoded LMP1 upregulates microRNA-21 to promote the resistance of nasopharyngeal carcinoma cells to cisplatin-induced Apoptosis by suppressing PDCD4 and Fas-L.
Yang GD, Huang TJ, Peng LX, Yang CF, Liu RY, Huang HB, Chu QQ, Yang HJ, Huang JL, Zhu ZY, Qian CN, Huang BJ. Yang GD, et al. Among authors: peng lx. PLoS One. 2013 Oct 23;8(10):e78355. doi: 10.1371/journal.pone.0078355. eCollection 2013. PLoS One. 2013. PMID: 24194922 Free PMC article.
Cancer stem-like cell characteristics induced by EB virus-encoded LMP1 contribute to radioresistance in nasopharyngeal carcinoma by suppressing the p53-mediated apoptosis pathway.
Yang CF, Peng LX, Huang TJ, Yang GD, Chu QQ, Liang YY, Cao X, Xie P, Zheng LS, Huang HB, Cai MD, Huang JL, Liu RY, Zhu ZY, Qian CN, Huang BJ. Yang CF, et al. Among authors: peng lx. Cancer Lett. 2014 Mar 28;344(2):260-71. doi: 10.1016/j.canlet.2013.11.006. Epub 2013 Nov 19. Cancer Lett. 2014. PMID: 24262659
Urokinase-type plasminogen activator receptor signaling is critical in nasopharyngeal carcinoma cell growth and metastasis.
Bao YN, Cao X, Luo DH, Sun R, Peng LX, Wang L, Yan YP, Zheng LS, Xie P, Cao Y, Liang YY, Zheng FJ, Huang BJ, Xiang YQ, Lv X, Chen QY, Chen MY, Huang PY, Guo L, Mai HQ, Guo X, Zeng YX, Qian CN. Bao YN, et al. Among authors: peng lx. Cell Cycle. 2014;13(12):1958-69. doi: 10.4161/cc.28921. Epub 2014 Apr 24. Cell Cycle. 2014. PMID: 24763226 Free PMC article.
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