Singh DK - Search Results

1

The Plasma Membrane Monoamine Transporter is Highly Expressed in Neuroblastoma and Functions as an mIBG Transporter.

Vieira LS, Zhang Y, López Quiñones AJ, Hu T, Singh DK, Stevens J, Prasad B, Park JR, Wang J. Vieira LS, et al. Among authors: singh dk. J Pharmacol Exp Ther. 2023 Dec;387(3):239-248. doi: 10.1124/jpet.123.001672. Epub 2023 Aug 4. J Pharmacol Exp Ther. 2023. PMID: 37541765 Free PMC article.

2

Dimethandrolone, a Potential Male Contraceptive Pill, is Primarily Metabolized by the Highly Polymorphic UDP-Glucuronosyltransferase 2B17 Enzyme in Human Intestine and Liver.

Sharma S, Ahire D, Basit A, Lajoie M, Wang C, Lee MS, Blithe DL, Amory JK, Singh DK, Heyward S, Prasad B. Sharma S, et al. Among authors: singh dk. Drug Metab Dispos. 2022 Dec;50(12):1493-1500. doi: 10.1124/dmd.122.001041. Epub 2022 Oct 2. Drug Metab Dispos. 2022. PMID: 36184078 Free PMC article.

3

Quantitative Characterization of Clinically Relevant Drug-Metabolizing Enzymes and Transporters in Rat Liver and Intestinal Segments for Applications in PBPK Modeling.

Sharma S, Singh DK, Mettu VS, Yue G, Ahire D, Basit A, Heyward S, Prasad B. Sharma S, et al. Among authors: singh dk. Mol Pharm. 2023 Mar 6;20(3):1737-1749. doi: 10.1021/acs.molpharmaceut.2c00950. Epub 2023 Feb 15. Mol Pharm. 2023. PMID: 36791335

4

Characterization of Xenobiotic and Steroid Disposition Potential of Human Placental Tissue and Cell Lines (BeWo, JEG-3, JAR, and HTR-8/SVneo) by Quantitative Proteomics.

Kruger L, Lapehn S, Paquette A, Singh DK, MacDonald J, Bammler TK, Enquobahrie DA, Zhao Q, Mozhui K, Sathyanarayana S, Prasad B. Kruger L, et al. Among authors: singh dk. Drug Metab Dispos. 2023 Aug;51(8):1053-1063. doi: 10.1124/dmd.123.001345. Epub 2023 May 10. Drug Metab Dispos. 2023. PMID: 37164652 Free PMC article.

5

Dissecting Parameters Contributing to the Underprediction of Aldehyde Oxidase-Mediated Metabolic Clearance of Drugs.

Subash S, Singh DK, Ahire DS, Khojasteh SC, Murray BP, Zientek MA, Jones RS, Kulkarni P, Smith BJ, Heyward S, Cronin CN, Prasad B. Subash S, et al. Among authors: singh dk. Drug Metab Dispos. 2023 Oct;51(10):1362-1371. doi: 10.1124/dmd.123.001379. Epub 2023 Jul 10. Drug Metab Dispos. 2023. PMID: 37429730

6

High-Throughput Assay of Cytochrome P450-Dependent Drug Demethylation Reactions and Its Use to Re-Evaluate the Pathways of Ketamine Metabolism.

Davydova NY, Hutner DA, Gaither KA, Singh DK, Prasad B, Davydov DR. Davydova NY, et al. Among authors: singh dk. Biology (Basel). 2023 Jul 27;12(8):1055. doi: 10.3390/biology12081055. Biology (Basel). 2023. PMID: 37626940 Free PMC article.

7

Effect of probenecid on blood levels and renal elimination of furosemide and endogenous compounds in rats: Discovery of putative organic anion transporter biomarkers.

Thakur A, Saradhi Mettu V, Singh DK, Prasad B. Thakur A, et al. Among authors: singh dk. Biochem Pharmacol. 2023 Dec;218:115867. doi: 10.1016/j.bcp.2023.115867. Epub 2023 Oct 20. Biochem Pharmacol. 2023. PMID: 37866801 Free PMC article.

8

Characterization of Gla proteoforms and non-Gla peptides of gamma carboxylated proteins: Application to quantification of prothrombin proteoforms in human plasma.

Singh DK, Basit A, Rettie AE, Alade N, Thummel K, Prasad B. Singh DK, et al. Anal Chim Acta. 2023 Dec 15;1284:341972. doi: 10.1016/j.aca.2023.341972. Epub 2023 Nov 5. Anal Chim Acta. 2023. PMID: 37996163 Free PMC article.

9

Effect of Cimetidine on Metformin Pharmacokinetics and Endogenous Metabolite Levels in Rats.

Ailabouni AS, Mettu VS, Thakur A, Singh DK, Prasad B. Ailabouni AS, et al. Among authors: singh dk. Drug Metab Dispos. 2024 Jan 9;52(2):86-94. doi: 10.1124/dmd.123.001470. Drug Metab Dispos. 2024. PMID: 38049999

10

Differential Tissue Abundance of Membrane-Bound Drug Metabolizing Enzymes and Transporter Proteins by Global Proteomics.

Singh DK, Ahire D, Davydov DR, Prasad B. Singh DK, et al. Drug Metab Dispos. 2024 Oct 16;52(11):1152-1160. doi: 10.1124/dmd.124.001477. Drug Metab Dispos. 2024. PMID: 38641346

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