Ishizaka ST - Search Results

1

A novel Toll-like receptor 7/8-specific antagonist E6742 ameliorates clinically relevant disease parameters in murine models of lupus.

Ishizaka ST, Hawkins L, Chen Q, Tago F, Yagi T, Sakaniwa K, Zhang Z, Shimizu T, Shirato M. Ishizaka ST, et al. Eur J Pharmacol. 2023 Oct 15;957:175962. doi: 10.1016/j.ejphar.2023.175962. Epub 2023 Aug 5. Eur J Pharmacol. 2023. PMID: 37544422 Free article.

2

First-in-Human Study of the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of E6742, a Dual Antagonist of Toll-like Receptors 7 and 8, in Healthy Volunteers.

Yamakawa N, Tago F, Nakai K, Kitahara Y, Ikari S, Hojo S, Hall N, Aluri J, Hussein Z, Gevorkyan H, Maruyama T, Ishizaka S, Yagi T. Yamakawa N, et al. Clin Pharmacol Drug Dev. 2023 Apr;12(4):363-375. doi: 10.1002/cpdd.1176. Epub 2022 Oct 11. Clin Pharmacol Drug Dev. 2023. PMID: 36219471 Clinical Trial.

3

LPS binding protein does not participate in the pharmacokinetics of E5564.

Kaneko K, Ueda R, Kawata T, Ishizaka S, Yoshimura T. Kaneko K, et al. J Endotoxin Res. 2004;10(3):185-94. doi: 10.1179/096805104225004860. J Endotoxin Res. 2004. PMID: 15198853

4

Assessment of the translational value of mouse lupus models using clinically relevant biomarkers.

Bender AT, Wu Y, Cao Q, Ding Y, Oestreicher J, Genest M, Akare S, Ishizaka ST, Mackey MF. Bender AT, et al. Among authors: ishizaka st. Transl Res. 2014 Jun;163(6):515-32. doi: 10.1016/j.trsl.2014.01.003. Epub 2014 Jan 6. Transl Res. 2014. PMID: 24462761

5

Novel small molecule inhibitors of TLR7 and TLR9: mechanism of action and efficacy in vivo.

Lamphier M, Zheng W, Latz E, Spyvee M, Hansen H, Rose J, Genest M, Yang H, Shaffer C, Zhao Y, Shen Y, Liu C, Liu D, Mempel TR, Rowbottom C, Chow J, Twine NC, Yu M, Gusovsky F, Ishizaka ST. Lamphier M, et al. Among authors: ishizaka st. Mol Pharmacol. 2014 Mar;85(3):429-40. doi: 10.1124/mol.113.089821. Epub 2013 Dec 16. Mol Pharmacol. 2014. PMID: 24342772

6

Effective antibody therapy induces host-protective antitumor immunity that is augmented by TLR4 agonist treatment.

Wang S, Astsaturov IA, Bingham CA, McCarthy KM, von Mehren M, Xu W, Alpaugh RK, Tang Y, Littlefield BA, Hawkins LD, Ishizaka ST, Weiner LM. Wang S, et al. Among authors: ishizaka st. Cancer Immunol Immunother. 2012 Jan;61(1):49-61. doi: 10.1007/s00262-011-1090-7. Epub 2011 Aug 13. Cancer Immunol Immunother. 2012. PMID: 21842208 Free PMC article.

7

Therapeutical targeting of nucleic acid-sensing Toll-like receptors prevents experimental cerebral malaria.

Franklin BS, Ishizaka ST, Lamphier M, Gusovsky F, Hansen H, Rose J, Zheng W, Ataíde MA, de Oliveira RB, Golenbock DT, Gazzinelli RT. Franklin BS, et al. Among authors: ishizaka st. Proc Natl Acad Sci U S A. 2011 Mar 1;108(9):3689-94. doi: 10.1073/pnas.1015406108. Epub 2011 Feb 8. Proc Natl Acad Sci U S A. 2011. PMID: 21303985 Free PMC article.

8

E6020: a synthetic Toll-like receptor 4 agonist as a vaccine adjuvant.

Ishizaka ST, Hawkins LD. Ishizaka ST, et al. Expert Rev Vaccines. 2007 Oct;6(5):773-84. doi: 10.1586/14760584.6.5.773. Expert Rev Vaccines. 2007. PMID: 17931157 Free article. Review.

9

Synthetic Toll-like receptor 4 agonist enhances vaccine efficacy in an experimental model of toxic shock syndrome.

Morefield GL, Hawkins LD, Ishizaka ST, Kissner TL, Ulrich RG. Morefield GL, et al. Among authors: ishizaka st. Clin Vaccine Immunol. 2007 Nov;14(11):1499-504. doi: 10.1128/CVI.00153-07. Epub 2007 Aug 22. Clin Vaccine Immunol. 2007. PMID: 17715328 Free PMC article.

10

Novel synthetic LPS receptor agonists boost systemic and mucosal antibody responses in mice.

Przetak M, Chow J, Cheng H, Rose J, Hawkins LD, Ishizaka ST. Przetak M, et al. Among authors: ishizaka st. Vaccine. 2003 Feb 14;21(9-10):961-70. doi: 10.1016/s0264-410x(02)00737-5. Vaccine. 2003. PMID: 12547609

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