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Impaired polyamine metabolism causes behavioral and neuroanatomical defects in a novel mouse model of Snyder-Robinson Syndrome.
Akinyele O, Munir A, Johnson MA, Perez MS, Gao Y, Foley JR, Wu Y, Murray-Stewart T, Casero RA Jr, Bayir H, Kemaladewi DU. Akinyele O, et al. Among authors: casero ra jr. bioRxiv [Preprint]. 2023 Feb 7:2023.01.15.524155. doi: 10.1101/2023.01.15.524155. bioRxiv. 2023. Update in: Dis Model Mech. 2024 Jun 1;17(6):dmm050639. doi: 10.1242/dmm.050639 PMID: 36711956 Free PMC article. Updated. Preprint.
Difluoromethylornithine rebalances aberrant polyamine ratios in Snyder-Robinson syndrome: mechanism of action and therapeutic potential.
Stewart TRM, Foley JR, Holbert CE, Khomutov MA, Rastkari N, Tao X, Khomutov AR, Zhai RG, Casero RA. Stewart TRM, et al. Among authors: casero ra. bioRxiv [Preprint]. 2023 Apr 10:2023.03.30.534977. doi: 10.1101/2023.03.30.534977. bioRxiv. 2023. Update in: EMBO Mol Med. 2023 Nov 8;15(11):e17833. doi: 10.15252/emmm.202317833 PMID: 37034775 Free PMC article. Updated. Preprint.
Androgen receptor drives polyamine synthesis creating a vulnerability for prostate cancer.
Kumar R, Jonnatan S, Sanin DE, Vakkala V, Kadam A, Kumar S, Dalrymple SL, Zhao L, Foley J, Holbert CE, Nwafor A, Kittane S, Penner E, Apostolova P, Warner S, Dang CV, Toska E, Thompson EA, Isaacs JT, De Marzo AM, Pearce EL, Stewart TM, Casero RA, Denmeade SR, Sena LA. Kumar R, et al. Among authors: casero ra. medRxiv [Preprint]. 2024 Dec 13:2024.12.12.24318845. doi: 10.1101/2024.12.12.24318845. medRxiv. 2024. PMID: 39711733 Free PMC article. Preprint.
LSD1 inhibition suppresses ASCL1 and de-represses YAP1 to drive potent activity against neuroendocrine prostate cancer.
Mandl A, Jasmine S, Krueger T, Kumar R, Coleman IM, Dalrymple SL, Antony L, Rosen DM, Jing Y, Hanratty B, Patel RA, Jin-Yih L, Dias J, Celatka CA, Tapper AE, Kleppe M, Kanayama M, Speranzini V, Wang YZ, Luo J, Corey E, Sena LA, Casero RA, Lotan T, Trock BJ, Kachhap SK, Denmeade SR, Carducci MA, Mattevi A, Haffner MC, Nelson PS, Rienhoff HY, Isaacs JT, Brennen WN. Mandl A, et al. Among authors: casero ra. bioRxiv [Preprint]. 2024 Jan 22:2024.01.17.576106. doi: 10.1101/2024.01.17.576106. bioRxiv. 2024. PMID: 38328141 Free PMC article. Preprint.
251 results