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Oncolytic Viruses Engineered to Enforce Leptin Expression Reprogram Tumor-Infiltrating T Cell Metabolism and Promote Tumor Clearance.
Rivadeneira DB, DePeaux K, Wang Y, Kulkarni A, Tabib T, Menk AV, Sampath P, Lafyatis R, Ferris RL, Sarkar SN, Thorne SH, Delgoffe GM. Rivadeneira DB, et al. Among authors: depeaux k. Immunity. 2019 Sep 17;51(3):548-560.e4. doi: 10.1016/j.immuni.2019.07.003. Epub 2019 Aug 27. Immunity. 2019. PMID: 31471106 Free PMC article.
Metabolic support of tumour-infiltrating regulatory T cells by lactic acid.
Watson MJ, Vignali PDA, Mullett SJ, Overacre-Delgoffe AE, Peralta RM, Grebinoski S, Menk AV, Rittenhouse NL, DePeaux K, Whetstone RD, Vignali DAA, Hand TW, Poholek AC, Morrison BM, Rothstein JD, Wendell SG, Delgoffe GM. Watson MJ, et al. Among authors: depeaux k. Nature. 2021 Mar;591(7851):645-651. doi: 10.1038/s41586-020-03045-2. Epub 2021 Feb 15. Nature. 2021. PMID: 33589820 Free PMC article.
Metabolic barriers to cancer immunotherapy.
DePeaux K, Delgoffe GM. DePeaux K, et al. Nat Rev Immunol. 2021 Dec;21(12):785-797. doi: 10.1038/s41577-021-00541-y. Epub 2021 Apr 29. Nat Rev Immunol. 2021. PMID: 33927375 Free PMC article. Review.
The Combined Effect of FGFR Inhibition and PD-1 Blockade Promotes Tumor-Intrinsic Induction of Antitumor Immunity.
Palakurthi S, Kuraguchi M, Zacharek SJ, Zudaire E, Huang W, Bonal DM, Liu J, Dhaneshwar A, DePeaux K, Gowaski MR, Bailey D, Regan SN, Ivanova E, Ferrante C, English JM, Khosla A, Beck AH, Rytlewski JA, Sanders C, Laquerre S, Bittinger MA, Kirschmeier PT, Packman K, Janne PA, Moy C, Wong KK, Verona RI, Lorenzi MV. Palakurthi S, et al. Among authors: depeaux k. Cancer Immunol Res. 2019 Sep;7(9):1457-1471. doi: 10.1158/2326-6066.CIR-18-0595. Epub 2019 Jul 22. Cancer Immunol Res. 2019. PMID: 31331945