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Page 1
The structural basis of hyperpromiscuity in a core combinatorial network of type II toxin-antitoxin and related phage defense systems.
Ernits K, Saha CK, Brodiazhenko T, Chouhan B, Shenoy A, Buttress JA, Duque-Pedraza JJ, Bojar V, Nakamoto JA, Kurata T, Egorov AA, Shyrokova L, Johansson MJO, Mets T, Rustamova A, Džigurski J, Tenson T, Garcia-Pino A, Strahl H, Elofsson A, Hauryliuk V, Atkinson GC. Ernits K, et al. Among authors: kurata t. Proc Natl Acad Sci U S A. 2023 Aug 15;120(33):e2305393120. doi: 10.1073/pnas.2305393120. Epub 2023 Aug 9. Proc Natl Acad Sci U S A. 2023. PMID: 37556498 Free PMC article.
A widespread toxin-antitoxin system exploiting growth control via alarmone signaling.
Jimmy S, Saha CK, Kurata T, Stavropoulos C, Oliveira SRA, Koh A, Cepauskas A, Takada H, Rejman D, Tenson T, Strahl H, Garcia-Pino A, Hauryliuk V, Atkinson GC. Jimmy S, et al. Among authors: kurata t. Proc Natl Acad Sci U S A. 2020 May 12;117(19):10500-10510. doi: 10.1073/pnas.1916617117. Epub 2020 Apr 28. Proc Natl Acad Sci U S A. 2020. PMID: 32345719 Free PMC article.
RelA-SpoT Homolog toxins pyrophosphorylate the CCA end of tRNA to inhibit protein synthesis.
Kurata T, Brodiazhenko T, Alves Oliveira SR, Roghanian M, Sakaguchi Y, Turnbull KJ, Bulvas O, Takada H, Tamman H, Ainelo A, Pohl R, Rejman D, Tenson T, Suzuki T, Garcia-Pino A, Atkinson GC, Hauryliuk V. Kurata T, et al. Mol Cell. 2021 Aug 5;81(15):3160-3170.e9. doi: 10.1016/j.molcel.2021.06.005. Epub 2021 Jun 25. Mol Cell. 2021. PMID: 34174184 Free article.
A hyperpromiscuous antitoxin protein domain for the neutralization of diverse toxin domains.
Kurata T, Saha CK, Buttress JA, Mets T, Brodiazhenko T, Turnbull KJ, Awoyomi OF, Oliveira SRA, Jimmy S, Ernits K, Delannoy M, Persson K, Tenson T, Strahl H, Hauryliuk V, Atkinson GC. Kurata T, et al. Proc Natl Acad Sci U S A. 2022 Feb 8;119(6):e2102212119. doi: 10.1073/pnas.2102212119. Proc Natl Acad Sci U S A. 2022. PMID: 35121656 Free PMC article.
Structural basis for HflXr-mediated antibiotic resistance in Listeria monocytogenes.
Koller TO, Turnbull KJ, Vaitkevicius K, Crowe-McAuliffe C, Roghanian M, Bulvas O, Nakamoto JA, Kurata T, Julius C, Atkinson GC, Johansson J, Hauryliuk V, Wilson DN. Koller TO, et al. Among authors: kurata t. Nucleic Acids Res. 2022 Oct 28;50(19):11285-11300. doi: 10.1093/nar/gkac934. Nucleic Acids Res. 2022. PMID: 36300626 Free PMC article.
Direct activation of a bacterial innate immune system by a viral capsid protein.
Zhang T, Tamman H, Coppieters 't Wallant K, Kurata T, LeRoux M, Srikant S, Brodiazhenko T, Cepauskas A, Talavera A, Martens C, Atkinson GC, Hauryliuk V, Garcia-Pino A, Laub MT. Zhang T, et al. Among authors: kurata t. Nature. 2022 Dec;612(7938):132-140. doi: 10.1038/s41586-022-05444-z. Epub 2022 Nov 16. Nature. 2022. PMID: 36385533 Free PMC article.
Mechanism of phage sensing and restriction by toxin-antitoxin-chaperone systems.
Mets T, Kurata T, Ernits K, Johansson MJO, Craig SZ, Evora GM, Buttress JA, Odai R, Wallant KC, Nakamoto JA, Shyrokova L, Egorov AA, Doering CR, Brodiazhenko T, Laub MT, Tenson T, Strahl H, Martens C, Harms A, Garcia-Pino A, Atkinson GC, Hauryliuk V. Mets T, et al. Among authors: kurata t. Cell Host Microbe. 2024 Jul 10;32(7):1059-1073.e8. doi: 10.1016/j.chom.2024.05.003. Epub 2024 May 30. Cell Host Microbe. 2024. PMID: 38821063 Free article.
Mechanisms of neutralization of toxSAS from toxin-antitoxin modules.
Dominguez-Molina L, Kurata T, Cepauskas A, Echemendia-Blanco D, Zedek S, Talavera-Perez A, Atkinson GC, Hauryliuk V, Garcia-Pino A. Dominguez-Molina L, et al. Among authors: kurata t. Nat Chem Biol. 2024 Jun 4. doi: 10.1038/s41589-024-01630-4. Online ahead of print. Nat Chem Biol. 2024. PMID: 38834893
991 results