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Utilization of Rosuvastatin and Endogenous Biomarkers in Evaluating the Impact of Ritlecitinib on BCRP, OATP1B1, and OAT3 Transporter Activity.
Huh Y, Plotka A, Wei H, Kaplan J, Raha N, Towner J, Purohit VS, Dowty ME, Wolk R, Vourvahis M, King-Ahmad A, Mathialagan S, West MA, Lazzaro S, Ryu S, Rodrigues AD. Huh Y, et al. Among authors: west ma. Pharm Res. 2023 Nov;40(11):2639-2651. doi: 10.1007/s11095-023-03564-3. Epub 2023 Aug 10. Pharm Res. 2023. PMID: 37561322 Free PMC article.
Quantitative Contribution of Six Major Transporters to the Hepatic Uptake of Drugs: "SLC-Phenotyping" Using Primary Human Hepatocytes.
Bi YA, Costales C, Mathialagan S, West M, Eatemadpour S, Lazzaro S, Tylaska L, Scialis R, Zhang H, Umland J, Kimoto E, Tess DA, Feng B, Tremaine LM, Varma MVS, Rodrigues AD. Bi YA, et al. J Pharmacol Exp Ther. 2019 Jul;370(1):72-83. doi: 10.1124/jpet.119.257600. Epub 2019 Apr 11. J Pharmacol Exp Ther. 2019. PMID: 30975793
Identification of Glycochenodeoxycholate 3-O-Glucuronide and Glycodeoxycholate 3-O-Glucuronide as Highly Sensitive and Specific OATP1B1 Biomarkers.
Neuvonen M, Hirvensalo P, Tornio A, Rago B, West M, Lazzaro S, Mathialagan S, Varma M, Cerny MA, Costales C, Ramanathan R, Rodrigues AD, Niemi M. Neuvonen M, et al. Among authors: west m. Clin Pharmacol Ther. 2021 Mar;109(3):646-657. doi: 10.1002/cpt.2053. Epub 2020 Oct 18. Clin Pharmacol Ther. 2021. PMID: 32961594 Free PMC article.
Organic Anion-Transporting Polypeptide 1B1/1B3-Mediated Hepatic Uptake Determines the Pharmacokinetics of Large Lipophilic Acids: In Vitro-In Vivo Evaluation in Cynomolgus Monkey.
Eng H, Bi YA, West MA, Ryu S, Yamaguchi E, Kosa RE, Tess DA, Griffith DA, Litchfield J, Kalgutkar AS, Varma MVS. Eng H, et al. Among authors: west ma. J Pharmacol Exp Ther. 2021 Apr;377(1):169-180. doi: 10.1124/jpet.120.000457. Epub 2021 Jan 28. J Pharmacol Exp Ther. 2021. PMID: 33509903
Quantitative prediction of breast cancer resistant protein mediated drug-drug interactions using physiologically-based pharmacokinetic modeling.
Costales C, Lin J, Kimoto E, Yamazaki S, Gosset JR, Rodrigues AD, Lazzaro S, West MA, West M, Varma MVS. Costales C, et al. Among authors: west m, west ma. CPT Pharmacometrics Syst Pharmacol. 2021 Sep;10(9):1018-1031. doi: 10.1002/psp4.12672. Epub 2021 Jul 20. CPT Pharmacometrics Syst Pharmacol. 2021. PMID: 34164937 Free PMC article.
Low molecular weight acids and OATP1B mediated hepatic clearance: In vitro and in vivo evaluation using novel hypoxia-inducible factor prolyl hydroxylase inhibitors (Dustats).
Bi YA, Jordan S, King-Ahmad A, West MA, Yamaguchi E, Ryu S, Mathialagan S, Tess DA, Varma MVS. Bi YA, et al. Among authors: west ma. Drug Metab Dispos. 2024 Feb 22:DMD-AR-2023-001630. doi: 10.1124/dmd.123.001630. Online ahead of print. Drug Metab Dispos. 2024. PMID: 38388380 Free article.
300 results