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Aerobic exercise prevents cardiomyocyte damage caused by oxidative stress in early cardiovascular disease by increasing vascularity while L-arginine supplementation prevents it by increasing activation of the enzyme nitric oxide synthase.
Bertoldi JMCRJ, Kindlovits R, Rocha HNM, Fernandes-Santos C, Gomes JLP, Oliveira EM, Muniz IC, Santos MM, Pereira JF, Rocha NG, Nóbrega ACLD, Medeiros RF. Bertoldi JMCRJ, et al. Braz J Med Biol Res. 2023 Aug 14;56:e12533. doi: 10.1590/1414-431X2023e12533. eCollection 2023. Braz J Med Biol Res. 2023. PMID: 37585913 Free PMC article.
Molecular mechanisms underlying fructose-induced cardiovascular disease: exercise, metabolic pathways and microRNAs.
Kindlovits R, Bertoldi JMCRJ, Rocha HNM, Bento-Bernardes T, Gomes JLP, de Oliveira EM, Muniz IC, Pereira JF, Fernandes-Santos C, Rocha NG, Nóbrega ACLD, Medeiros RF. Kindlovits R, et al. Among authors: bertoldi jmcrj. Exp Physiol. 2021 May;106(5):1224-1234. doi: 10.1113/EP088845. Epub 2021 Mar 18. Exp Physiol. 2021. PMID: 33608966 Free article.