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KCTD1 is a new modulator of the KCASH family of Hedgehog suppressors.
Di Fiore A, Bellardinelli S, Pirone L, Russo R, Angrisani A, Terriaca G, Bowen M, Bordin F, Besharat ZM, Canettieri G, Fabretti F, Di Gaetano S, Di Marcotullio L, Pedone E, Moretti M, De Smaele E. Di Fiore A, et al. Among authors: terriaca g. Neoplasia. 2023 Sep;43:100926. doi: 10.1016/j.neo.2023.100926. Epub 2023 Aug 17. Neoplasia. 2023. PMID: 37597490 Free PMC article.
SMURF1 and SMURF2 directly target GLI1 for ubiquitination and proteasome-dependent degradation.
Bordin F, Terriaca G, Apostolico A, Di Fiore A, Mir FT, Bellardinelli S, Bufalieri F, Bordone R, Bellardinilli F, Giannini G, Canettieri G, Di Marcotullio L, Ferretti E, Moretti M, De Smaele E. Bordin F, et al. Among authors: terriaca g. Cell Death Discov. 2024 Dec 18;10(1):498. doi: 10.1038/s41420-024-02260-4. Cell Death Discov. 2024. PMID: 39695131 Free PMC article.