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Ultra-low volume intradermal administration of radiation-attenuated sporozoites with the glycolipid adjuvant 7DW8-5 completely protects mice against malaria.
Watson FN, Shears MJ, Kalata AC, Duncombe CJ, Seilie AM, Chavtur C, Conrad E, Talavera IC, Raappana A, Sather DN, Chakravarty S, Sim BKL, Hoffman SL, Tsuji M, Murphy SC. Watson FN, et al. Among authors: murphy sc. Res Sq [Preprint]. 2023 Aug 11:rs.3.rs-3243319. doi: 10.21203/rs.3.rs-3243319/v1. Res Sq. 2023. Update in: Sci Rep. 2024 Feb 4;14(1):2881. doi: 10.1038/s41598-024-53118-9 PMID: 37609210 Free PMC article. Updated. Preprint.
Increased sample volume and use of quantitative reverse-transcription PCR can improve prediction of liver-to-blood inoculum size in controlled human malaria infection studies.
Hodgson SH, Douglas AD, Edwards NJ, Kimani D, Elias SC, Chang M, Daza G, Seilie AM, Magiri C, Muia A, Juma EA, Cole AO, Rampling TW, Anagnostou NA, Gilbert SC, Hoffman SL, Draper SJ, Bejon P, Ogutu B, Marsh K, Hill AV, Murphy SC. Hodgson SH, et al. Among authors: murphy sc. Malar J. 2015 Jan 28;14:33. doi: 10.1186/s12936-015-0541-6. Malar J. 2015. PMID: 25627033 Free PMC article.
Complete attenuation of genetically engineered Plasmodium falciparum sporozoites in human subjects.
Kublin JG, Mikolajczak SA, Sack BK, Fishbaugher ME, Seilie A, Shelton L, VonGoedert T, Firat M, Magee S, Fritzen E, Betz W, Kain HS, Dankwa DA, Steel RW, Vaughan AM, Noah Sather D, Murphy SC, Kappe SH. Kublin JG, et al. Among authors: murphy sc. Sci Transl Med. 2017 Jan 4;9(371):eaad9099. doi: 10.1126/scitranslmed.aad9099. Sci Transl Med. 2017. PMID: 28053159 Clinical Trial.
Humoral protection against mosquito bite-transmitted Plasmodium falciparum infection in humanized mice.
Sack BK, Mikolajczak SA, Fishbaugher M, Vaughan AM, Flannery EL, Nguyen T, Betz W, Jane Navarro M, Foquet L, Steel RWJ, Billman ZP, Murphy SC, Hoffman SL, Chakravarty S, Sim BKL, Behet M, Reuling IJ, Walk J, Scholzen A, Sauerwein RW, Ishizuka AS, Flynn B, Seder RA, Kappe SHI. Sack BK, et al. Among authors: murphy sc. NPJ Vaccines. 2017 Oct 9;2:27. doi: 10.1038/s41541-017-0028-2. eCollection 2017. NPJ Vaccines. 2017. PMID: 29263882 Free PMC article.
A human monoclonal antibody prevents malaria infection by targeting a new site of vulnerability on the parasite.
Kisalu NK, Idris AH, Weidle C, Flores-Garcia Y, Flynn BJ, Sack BK, Murphy S, Schön A, Freire E, Francica JR, Miller AB, Gregory J, March S, Liao HX, Haynes BF, Wiehe K, Trama AM, Saunders KO, Gladden MA, Monroe A, Bonsignori M, Kanekiyo M, Wheatley AK, McDermott AB, Farney SK, Chuang GY, Zhang B, Kc N, Chakravarty S, Kwong PD, Sinnis P, Bhatia SN, Kappe SHI, Sim BKL, Hoffman SL, Zavala F, Pancera M, Seder RA. Kisalu NK, et al. Nat Med. 2018 May;24(4):408-416. doi: 10.1038/nm.4512. Epub 2018 Mar 19. Nat Med. 2018. PMID: 29554083 Free PMC article.
Screening for Pfhrp2/3-Deleted Plasmodium falciparum, Non-falciparum, and Low-Density Malaria Infections by a Multiplex Antigen Assay.
Plucinski MM, Herman C, Jones S, Dimbu R, Fortes F, Ljolje D, Lucchi N, Murphy SC, Smith NT, Cruz KR, Seilie AM, Halsey ES, Udhayakumar V, Aidoo M, Rogier E. Plucinski MM, et al. Among authors: murphy sc. J Infect Dis. 2019 Jan 9;219(3):437-447. doi: 10.1093/infdis/jiy525. J Infect Dis. 2019. PMID: 30202972 Free PMC article.
167 results