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The replication-competent HIV reservoir is a genetically restricted, younger subset of the overall pool of HIV proviruses persisting during therapy, which is highly genetically stable over time.
Shahid A, MacLennan S, Jones BR, Sudderuddin H, Dang Z, Cobamibias K, Duncan MC, Kinloch NN, Dapp MJ, Archin NM, Fischl MA, Ofotokun I, Adimora A, Gange S, Aouizerat B, Kuniholm MH, Kassaye S, Mullins JI, Goldstein H, Joy JB, Anastos K, Brumme ZL. Shahid A, et al. Among authors: joy jb. Res Sq [Preprint]. 2023 Aug 16:rs.3.rs-3259040. doi: 10.21203/rs.3.rs-3259040/v1. Res Sq. 2023. Update in: J Virol. 2024 Feb 20;98(2):e0165523. doi: 10.1128/jvi.01655-23. PMID: 37645749 Free PMC article. Updated. Preprint.
Phylogenetic approach to recover integration dates of latent HIV sequences within-host.
Jones BR, Kinloch NN, Horacsek J, Ganase B, Harris M, Harrigan PR, Jones RB, Brockman MA, Joy JB, Poon AFY, Brumme ZL. Jones BR, et al. Among authors: joy jb. Proc Natl Acad Sci U S A. 2018 Sep 18;115(38):E8958-E8967. doi: 10.1073/pnas.1802028115. Epub 2018 Sep 5. Proc Natl Acad Sci U S A. 2018. PMID: 30185556 Free PMC article.
HIV Diversity and Genetic Compartmentalization in Blood and Testes during Suppressive Antiretroviral Therapy.
Miller RL, Ponte R, Jones BR, Kinloch NN, Omondi FH, Jenabian MA, Dupuy FP, Fromentin R, Brassard P, Mehraj V, Chomont N, Poon AFY, Joy JB, Brumme ZL, Routy JP; ORCHID Study Group. Miller RL, et al. Among authors: joy jb. J Virol. 2019 Aug 13;93(17):e00755-19. doi: 10.1128/JVI.00755-19. Print 2019 Sep 1. J Virol. 2019. PMID: 31189714 Free PMC article.
Genetic Diversity, Compartmentalization, and Age of HIV Proviruses Persisting in CD4+ T Cell Subsets during Long-Term Combination Antiretroviral Therapy.
Jones BR, Miller RL, Kinloch NN, Tsai O, Rigsby H, Sudderuddin H, Shahid A, Ganase B, Brumme CJ, Harris M, Poon AFY, Brockman MA, Fromentin R, Chomont N, Joy JB, Brumme ZL. Jones BR, et al. Among authors: joy jb. J Virol. 2020 Feb 14;94(5):e01786-19. doi: 10.1128/JVI.01786-19. Print 2020 Feb 14. J Virol. 2020. PMID: 31776273 Free PMC article.
HIV-1 variants are archived throughout infection and persist in the reservoir.
Brooks K, Jones BR, Dilernia DA, Wilkins DJ, Claiborne DT, McInally S, Gilmour J, Kilembe W, Joy JB, Allen SA, Brumme ZL, Hunter E. Brooks K, et al. Among authors: joy jb. PLoS Pathog. 2020 Jun 3;16(6):e1008378. doi: 10.1371/journal.ppat.1008378. eCollection 2020 Jun. PLoS Pathog. 2020. PMID: 32492044 Free PMC article. Clinical Trial.
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