Wang H - Search Results

1

Informing virtual clinical trials of hepatocellular carcinoma with spatial multi-omics analysis of a human neoadjuvant immunotherapy clinical trial.

Zhang S, Deshpande A, Verma BK, Wang H, Mi H, Yuan L, Ho WJ, Jaffee EM, Zhu Q, Anders RA, Yarchoan M, Kagohara LT, Fertig EJ, Popel AS. Zhang S, et al. Among authors: wang h. bioRxiv [Preprint]. 2023 Aug 15:2023.08.11.553000. doi: 10.1101/2023.08.11.553000. bioRxiv. 2023. PMID: 37645761 Free PMC article. Preprint.

2

In silico simulation of a clinical trial with anti-CTLA-4 and anti-PD-L1 immunotherapies in metastatic breast cancer using a systems pharmacology model.

Wang H, Milberg O, Bartelink IH, Vicini P, Wang B, Narwal R, Roskos L, Santa-Maria CA, Popel AS. Wang H, et al. Among authors: wang b. R Soc Open Sci. 2019 May 22;6(5):190366. doi: 10.1098/rsos.190366. eCollection 2019 May. R Soc Open Sci. 2019. PMID: 31218069 Free PMC article.

3

Conducting a Virtual Clinical Trial in HER2-Negative Breast Cancer Using a Quantitative Systems Pharmacology Model With an Epigenetic Modulator and Immune Checkpoint Inhibitors.

Wang H, Sové RJ, Jafarnejad M, Rahmeh S, Jaffee EM, Stearns V, Roussos Torres ET, Connolly RM, Popel AS. Wang H, et al. Front Bioeng Biotechnol. 2020 Feb 25;8:141. doi: 10.3389/fbioe.2020.00141. eCollection 2020. Front Bioeng Biotechnol. 2020. PMID: 32158754 Free PMC article.

4

A Quantitative Systems Pharmacology Model of T Cell Engager Applied to Solid Tumor.

Ma H, Wang H, Sove RJ, Jafarnejad M, Tsai CH, Wang J, Giragossian C, Popel AS. Ma H, et al. Among authors: wang h, wang j. AAPS J. 2020 Jun 12;22(4):85. doi: 10.1208/s12248-020-00450-3. AAPS J. 2020. PMID: 32533270 Free PMC article.

5

QSP-IO: A Quantitative Systems Pharmacology Toolbox for Mechanistic Multiscale Modeling for Immuno-Oncology Applications.

Sové RJ, Jafarnejad M, Zhao C, Wang H, Ma H, Popel AS. Sové RJ, et al. Among authors: wang h. CPT Pharmacometrics Syst Pharmacol. 2020 Sep;9(9):484-497. doi: 10.1002/psp4.12546. Epub 2020 Sep 7. CPT Pharmacometrics Syst Pharmacol. 2020. PMID: 32618119 Free PMC article.

6

Combination therapy with T cell engager and PD-L1 blockade enhances the antitumor potency of T cells as predicted by a QSP model.

Ma H, Wang H, Sové RJ, Wang J, Giragossian C, Popel AS. Ma H, et al. Among authors: wang h, wang j. J Immunother Cancer. 2020 Aug;8(2):e001141. doi: 10.1136/jitc-2020-001141. J Immunother Cancer. 2020. PMID: 32859743 Free PMC article.

7

Quantitative systems pharmacology model predictions for efficacy of atezolizumab and nab-paclitaxel in triple-negative breast cancer.

Wang H, Ma H, Sové RJ, Emens LA, Popel AS. Wang H, et al. J Immunother Cancer. 2021 Feb;9(2):e002100. doi: 10.1136/jitc-2020-002100. J Immunother Cancer. 2021. PMID: 33579739 Free PMC article.

8

Integrating single cell sequencing with a spatial quantitative systems pharmacology model spQSP for personalized prediction of triple-negative breast cancer immunotherapy response.

Zhang S, Gong C, Ruiz-Martinez A, Wang H, Davis-Marcisak E, Deshpande A, Popel AS, Fertig EJ. Zhang S, et al. Among authors: wang h. Immunoinformatics (Amst). 2021 Oct;1-2:100002. doi: 10.1016/j.immuno.2021.100002. Epub 2021 Jul 24. Immunoinformatics (Amst). 2021. PMID: 34708216 Free PMC article.

9

Systems biology of angiogenesis signaling: Computational models and omics.

Zhang Y, Wang H, Oliveira RHM, Zhao C, Popel AS. Zhang Y, et al. Among authors: wang h. WIREs Mech Dis. 2022 Jul;14(4):e1550. doi: 10.1002/wsbm.1550. Epub 2021 Dec 30. WIREs Mech Dis. 2022. PMID: 34970866 Free PMC article. Review.

10

Dynamics of tumor-associated macrophages in a quantitative systems pharmacology model of immunotherapy in triple-negative breast cancer.

Wang H, Zhao C, Santa-Maria CA, Emens LA, Popel AS. Wang H, et al. iScience. 2022 Jun 30;25(8):104702. doi: 10.1016/j.isci.2022.104702. eCollection 2022 Aug 19. iScience. 2022. PMID: 35856032 Free PMC article.

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