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16 results

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Page 1
Discovery of ABBV-154, an anti-TNF Glucocorticoid Receptor Modulator Immunology Antibody-Drug Conjugate (iADC).
Hobson AD, Xu J, Welch DS, Marvin CC, McPherson MJ, Gates B, Liao X, Hollmann M, Gattner MJ, Dzeyk K, Sarvaiya H, Shenoy VM, Fettis MM, Bischoff AK, Wang L, Santora LC, Wang L, Fitzgibbons J, Salomon P, Hernandez A Jr, Jia Y, Goess CA, Mathieu SL, Bryant SH, Larsen ME, Cui B, Tian Y. Hobson AD, et al. Among authors: fettis mm. J Med Chem. 2023 Sep 14;66(17):12544-12558. doi: 10.1021/acs.jmedchem.3c01174. Epub 2023 Sep 1. J Med Chem. 2023. PMID: 37656698
Discovery of ABBV-3373, an Anti-TNF Glucocorticoid Receptor Modulator Immunology Antibody Drug Conjugate.
Hobson AD, McPherson MJ, Hayes ME, Goess C, Li X, Zhou J, Wang Z, Yu Y, Yang J, Sun L, Zhang Q, Qu P, Yang S, Hernandez A Jr, Bryant SH, Mathieu SL, Bischoff AK, Fitzgibbons J, Santora LC, Wang L, Wang L, Fettis MM, Li X, Marvin CC, Wang Z, Patel MV, Schmidt DL, Li T, Randolph JT, Henry RF, Graff C, Tian Y, Aguirre AL, Shrestha A. Hobson AD, et al. Among authors: fettis mm. J Med Chem. 2022 Dec 8;65(23):15893-15934. doi: 10.1021/acs.jmedchem.2c01579. Epub 2022 Nov 17. J Med Chem. 2022. PMID: 36394224
Correction to "Discovery of ABBV-3373, an Anti-TNF Glucocorticoid Receptor Modulator Immunology Antibody Drug Conjugate".
Hobson AD, McPherson MJ, Hayes ME, Goess C, Li X, Zhou J, Wang Z, Yu Y, Yang J, Sun L, Zhang Q, Qu P, Yang S, Hernandez A Jr, Bryant SH, Mathieu SL, Bischoff AK, Fitzgibbons J, Santora LC, Wang L, Wang L, Fettis MM, Li X, Marvin CC, Wang Z, Patel MV, Schmidt DL, Li T, Randolph JT, Henry RF, Graff C, Tian Y, Aguirre AL, Shrestha A. Hobson AD, et al. Among authors: fettis mm. J Med Chem. 2023 Apr 27;66(8):6010. doi: 10.1021/acs.jmedchem.3c00494. Epub 2023 Apr 7. J Med Chem. 2023. PMID: 37027784 No abstract available.
Optimization of Drug-Linker to Enable Long-term Storage of Antibody-Drug Conjugate for Subcutaneous Dosing.
Hobson AD, Xu J, Marvin CC, McPherson MJ, Hollmann M, Gattner M, Dzeyk K, Fettis MM, Bischoff AK, Wang L, Fitzgibbons J, Wang L, Salomon P, Hernandez A Jr, Jia Y, Sarvaiya H, Goess CA, Mathieu SL, Santora LC. Hobson AD, et al. Among authors: fettis mm. J Med Chem. 2023 Jul 13;66(13):9161-9173. doi: 10.1021/acs.jmedchem.3c00794. Epub 2023 Jun 28. J Med Chem. 2023. PMID: 37379257
Self-Immolative Carbamate Linkers for CD19-Budesonide Antibody-Drug Conjugates.
Marvin CC, Hobson AD, McPherson M, Dunstan TA, Vargo TR, Hayes ME, Fettis MM, Bischoff A, Wang L, Wang L, Hernandez A Jr, Jia Y, Oh JZ, Tian Y. Marvin CC, et al. Among authors: fettis mm. Bioconjug Chem. 2023 Oct 18;34(10):1835-1850. doi: 10.1021/acs.bioconjchem.3c00354. Epub 2023 Oct 3. Bioconjug Chem. 2023. PMID: 37788373
Suppression of local inflammation via galectin-anchored indoleamine 2,3-dioxygenase.
Bracho-Sanchez E, Rocha FG, Bedingfield SK, Partain BD, Macias SL, Brusko MA, Colazo JM, Fettis MM, Farhadi SA, Helm EY, Koenders K, Kwiatkowski AJ, Restuccia A, Morales BS, Wanchoo A, Avram D, Allen KD, Duvall CL, Wallet SM, Hudalla GA, Keselowsky BG. Bracho-Sanchez E, et al. Among authors: fettis mm. Nat Biomed Eng. 2023 Sep;7(9):1156-1169. doi: 10.1038/s41551-023-01025-1. Epub 2023 May 1. Nat Biomed Eng. 2023. PMID: 37127708 Free PMC article.
Intracellular immune sensing promotes inflammation via gasdermin D-driven release of a lectin alarmin.
Russo AJ, Vasudevan SO, Méndez-Huergo SP, Kumari P, Menoret A, Duduskar S, Wang C, Pérez Sáez JM, Fettis MM, Li C, Liu R, Wanchoo A, Chandiran K, Ruan J, Vanaja SK, Bauer M, Sponholz C, Hudalla GA, Vella AT, Zhou B, Deshmukh SD, Rabinovich GA, Rathinam VA. Russo AJ, et al. Among authors: fettis mm. Nat Immunol. 2021 Feb;22(2):154-165. doi: 10.1038/s41590-020-00844-7. Epub 2021 Jan 4. Nat Immunol. 2021. PMID: 33398185 Free PMC article.
16 results