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Introducing of novel class of pyrano[2,3-c]pyrazole-5-carbonitrile analogs with potent antimicrobial activity, DNA gyrase inhibition, and prominent pharmacokinetic and CNS toxicity profiles supported by molecular dynamic simulation.
Almaghrabi M, Musa A, Aljohani AKB, Ahmed HEA, Alsulaimany M, Miski SF, Mostafa EM, Hussein S, Parambi DGT, Ghoneim MM, Elgammal WE, Halawa AH, Hammad A, El-Agrody AM. Almaghrabi M, et al. Among authors: elgammal we. J Biomol Struct Dyn. 2024 Nov;42(18):9529-9546. doi: 10.1080/07391102.2023.2252088. Epub 2023 Sep 3. J Biomol Struct Dyn. 2024. PMID: 37661733
16 results