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Engineered lentivirus-derived nanoparticles (LVNPs) for delivery of CRISPR/Cas ribonucleoprotein complexes supporting base editing, prime editing and in vivo gene modification.
Haldrup J, Andersen S, Labial ARL, Wolff JH, Frandsen FP, Skov TW, Rovsing AB, Nielsen I, Jakobsen TS, Askou AL, Thomsen MK, Corydon TJ, Thomsen EA, Mikkelsen JG. Haldrup J, et al. Nucleic Acids Res. 2023 Oct 13;51(18):10059-10074. doi: 10.1093/nar/gkad676. Nucleic Acids Res. 2023. PMID: 37678882 Free PMC article.
pegIT - a web-based design tool for prime editing.
Anderson MV, Haldrup J, Thomsen EA, Wolff JH, Mikkelsen JG. Anderson MV, et al. Among authors: haldrup j. Nucleic Acids Res. 2021 Jul 2;49(W1):W505-W509. doi: 10.1093/nar/gkab427. Nucleic Acids Res. 2021. PMID: 34060619 Free PMC article.
A truncated reverse transcriptase enhances prime editing by split AAV vectors.
Gao Z, Ravendran S, Mikkelsen NS, Haldrup J, Cai H, Ding X, Paludan SR, Thomsen MK, Mikkelsen JG, Bak RO. Gao Z, et al. Among authors: haldrup j. Mol Ther. 2022 Sep 7;30(9):2942-2951. doi: 10.1016/j.ymthe.2022.07.001. Epub 2022 Jul 8. Mol Ther. 2022. PMID: 35808824 Free PMC article.
A genome-wide CRISPR-Cas9 knockout screen identifies novel PARP inhibitor resistance genes in prostate cancer.
Ipsen MB, Sørensen EMG, Thomsen EA, Weiss S, Haldrup J, Dalby A, Palmfeldt J, Bross P, Rasmussen M, Fredsøe J, Klingenberg S, Jochumsen MR, Bouchelouche K, Ulhøi BP, Borre M, Mikkelsen JG, Sørensen KD. Ipsen MB, et al. Among authors: haldrup j. Oncogene. 2022 Sep;41(37):4271-4281. doi: 10.1038/s41388-022-02427-2. Epub 2022 Aug 6. Oncogene. 2022. PMID: 35933519
FRMD6 has tumor suppressor functions in prostate cancer.
Haldrup J, Strand SH, Cieza-Borrella C, Jakobsson ME, Riedel M, Norgaard M, Hedensted S, Dagnaes-Hansen F, Ulhoi BP, Eeles R, Borre M, Olsen JV, Thomsen M, Kote-Jarai Z, Sorensen KD. Haldrup J, et al. Oncogene. 2021 Jan;40(4):763-776. doi: 10.1038/s41388-020-01548-w. Epub 2020 Nov 28. Oncogene. 2021. PMID: 33249427