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Fully synthetic Tn-based three-component cancer vaccine using covalently linked TLR4 ligand MPLA and iNKT cell agonist KRN-7000 as built-in adjuvant effectively protects mice from tumor development.
Yang D, Luo X, Lian Q, Gao L, Wang C, Qi X, Zhang R, Liu Z, Liao G. Yang D, et al. Among authors: zhang r. Acta Pharm Sin B. 2022 Dec;12(12):4432-4445. doi: 10.1016/j.apsb.2022.05.028. Epub 2022 May 30. Acta Pharm Sin B. 2022. PMID: 36561989 Free PMC article.
Luteolin exhibits synergistic therapeutic efficacy with erastin to induce ferroptosis in colon cancer cells through the HIC1-mediated inhibition of GPX4 expression.
Zheng Y, Li L, Chen H, Zheng Y, Tan X, Zhang G, Jiang R, Yu H, Lin S, Wei Y, Wang Y, Zhang R, Liu Z, Wu J. Zheng Y, et al. Among authors: zhang r, zhang g. Free Radic Biol Med. 2023 Nov 1;208:530-544. doi: 10.1016/j.freeradbiomed.2023.09.014. Epub 2023 Sep 17. Free Radic Biol Med. 2023. PMID: 37717793
Formononetin, a bioactive isoflavonoid constituent from Astragalus membranaceus (Fisch.) Bunge, ameliorates type 1 diabetes mellitus via activation of Keap1/Nrf2 signaling pathway: An integrated study supported by network pharmacology and experimental validation.
Chen H, Lou Y, Lin S, Tan X, Zheng Y, Yu H, Jiang R, Wei Y, Huang H, Qi X, Zhang R, Liu Z, Wu J. Chen H, et al. Among authors: zhang r. J Ethnopharmacol. 2024 Mar 25;322:117576. doi: 10.1016/j.jep.2023.117576. Epub 2023 Dec 15. J Ethnopharmacol. 2024. PMID: 38104880
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