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Page 1
Pervasive nuclear envelope ruptures precede ECM signaling and disease onset without activating cGAS-STING in Lamin-cardiomyopathy mice.
En A, Bogireddi H, Thomas B, Stutzman A, Ikegami S, LaForest B, Almakki O, Pytel P, Moskowitz IP, Ikegami K. En A, et al. Among authors: laforest b. bioRxiv [Preprint]. 2024 Apr 18:2023.08.28.555134. doi: 10.1101/2023.08.28.555134. bioRxiv. 2024. Update in: Cell Rep. 2024 Jun 25;43(6):114284. doi: 10.1016/j.celrep.2024.114284 PMID: 37693381 Free PMC article. Updated. Preprint.
A Genomic Link From Heart Failure to Atrial Fibrillation Risk: FOG2 Modulates a TBX5/GATA4-Dependent Atrial Gene Regulatory Network.
Broman MT, Nadadur RD, Perez-Cervantes C, Burnicka-Turek O, Lazarevic S, Gams A, Laforest B, Steimle JD, Iddir S, Wang Z, Smith L, Mazurek SR, Olivey HE, Zhou P, Gadek M, Shen KM, Khan Z, Theisen JWM, Yang XH, Ikegami K, Efimov IR, Pu WT, Weber CR, McNally EM, Svensson EC, Moskowitz IP. Broman MT, et al. Among authors: laforest b. Circulation. 2024 Apr 9;149(15):1205-1230. doi: 10.1161/CIRCULATIONAHA.123.066804. Epub 2024 Jan 8. Circulation. 2024. PMID: 38189150
Discovery of First Branched-Chain Ketoacid Dehydrogenase Kinase (BDK) Inhibitor Clinical Candidate PF-07328948.
Filipski KJ, Martinez-Alsina LA, Reese MR, Evrard E, Buzon LM, Cameron KO, Zhang Y, Coffman KJ, Bradow J, Kormos BL, Liu S, Knafels JD, Sahasrabudhe PV, Chen J, Kalgutkar AS, Bessire AJ, Orozco CC, Balesano A, Cerny MA, Bollinger E, Reyes AR, Laforest B, Rosado A, Williams G, Marshall M, Tam Neale K, Chen X, Hirenallur-Shanthappa D, Stansfield JC, Groarke J, Qiu R, Karas S, Roth Flach RJ, Esler WP. Filipski KJ, et al. Among authors: laforest b. J Med Chem. 2024 Nov 19. doi: 10.1021/acs.jmedchem.4c02230. Online ahead of print. J Med Chem. 2024. PMID: 39560668
Small molecule branched-chain ketoacid dehydrogenase kinase (BDK) inhibitors with opposing effects on BDK protein levels.
Roth Flach RJ, Bollinger E, Reyes AR, Laforest B, Kormos BL, Liu S, Reese MR, Martinez Alsina LA, Buzon L, Zhang Y, Bechle B, Rosado A, Sahasrabudhe PV, Knafels J, Bhattacharya SK, Omoto K, Stansfield JC, Hurley LD, Song L, Luo L, Breitkopf SB, Monetti M, Cunio T, Tierney B, Geoly FJ, Delmore J, Siddall CP, Xue L, Yip KN, Kalgutkar AS, Miller RA, Zhang BB, Filipski KJ. Roth Flach RJ, et al. Among authors: laforest b. Nat Commun. 2023 Aug 9;14(1):4812. doi: 10.1038/s41467-023-40536-y. Nat Commun. 2023. PMID: 37558654 Free PMC article.
Partial and complete loss of myosin binding protein H-like cause cardiac conduction defects.
Barefield DY, Yamakawa S, Tahtah I, Sell JJ, Broman M, Laforest B, Harris S, Alvarez-Arce A, Araujo KN, Puckelwartz MJ, Wasserstrom JA, Fishman GI, McNally EM. Barefield DY, et al. Among authors: laforest b. J Mol Cell Cardiol. 2022 Aug;169:28-40. doi: 10.1016/j.yjmcc.2022.04.012. Epub 2022 May 6. J Mol Cell Cardiol. 2022. PMID: 35533732 Free PMC article.
Hox-dependent coordination of mouse cardiac progenitor cell patterning and differentiation.
Stefanovic S, Laforest B, Desvignes JP, Lescroart F, Argiro L, Maurel-Zaffran C, Salgado D, Plaindoux E, De Bono C, Pazur K, Théveniau-Ruissy M, Béroud C, Puceat M, Gavalas A, Kelly RG, Zaffran S. Stefanovic S, et al. Among authors: laforest b. Elife. 2020 Aug 17;9:e55124. doi: 10.7554/eLife.55124. Elife. 2020. PMID: 32804075 Free PMC article.
ZO-1 Regulates Intercalated Disc Composition and Atrioventricular Node Conduction.
Dai W, Nadadur RD, Brennan JA, Smith HL, Shen KM, Gadek M, Laforest B, Wang M, Gemel J, Li Y, Zhang J, Ziman BD, Yan J, Ai X, Beyer EC, Lakata EG, Kasthuri N, Efimov IR, Broman MT, Moskowitz IP, Shen L, Weber CR. Dai W, et al. Among authors: laforest b. Circ Res. 2020 Jul 3;127(2):e28-e43. doi: 10.1161/CIRCRESAHA.119.316415. Epub 2020 Apr 29. Circ Res. 2020. PMID: 32347164 Free PMC article.
24 results