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APOE4/4 is linked to damaging lipid droplets in Alzheimer's microglia.
Haney MS, Pálovics R, Munson CN, Long C, Johansson P, Yip O, Dong W, Rawat E, West E, Schlachetzki JC, Tsai A, Guldner IH, Lamichhane BS, Smith A, Schaum N, Calcuttawala K, Shin A, Wang YH, Wang C, Koutsodendris N, Serrano GE, Beach TG, Reiman EM, Glass CK, Abu-Remaileh M, Enejder A, Huang Y, Wyss-Coray T. Haney MS, et al. Among authors: huang y. bioRxiv [Preprint]. 2023 Jul 25:2023.07.21.549930. doi: 10.1101/2023.07.21.549930. bioRxiv. 2023. Update in: Nature. 2024 Apr;628(8006):154-161. doi: 10.1038/s41586-024-07185-7 PMID: 37546938 Free PMC article. Updated. Preprint.
Data-driven discovery of cell-type-directed network-correcting combination therapy for Alzheimer's disease.
Li Y, Serras CP, Blumenfeld J, Xie M, Hao Y, Deng E, Chun YY, Holtzman J, An A, Yoon SY, Tang X, Rao A, Woldemariam S, Tang A, Zhang A, Simms J, Lo I, Oskotsky T, Keiser MJ, Huang Y, Sirota M. Li Y, et al. Among authors: huang y. bioRxiv [Preprint]. 2024 Dec 13:2024.12.09.627436. doi: 10.1101/2024.12.09.627436. bioRxiv. 2024. PMID: 39713353 Free PMC article. Preprint.
Report of the APOE4 National Institute on Aging/Alzheimer Disease Sequencing Project Consortium Working Group: Reducing APOE4 in Carriers is a Therapeutic Goal for Alzheimer's Disease.
Vance JM, Farrer LA, Huang Y, Cruchaga C, Hyman BT, Pericak-Vance MA, Goate AM, Greicius MD, Griswold AJ, Haines JL, Tcw J, Schellenberg GD, Tsai LH, Herz J, Holtzman DM. Vance JM, et al. Among authors: huang y. Ann Neurol. 2024 Apr;95(4):625-634. doi: 10.1002/ana.26864. Epub 2024 Jan 5. Ann Neurol. 2024. PMID: 38180638 Review.
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