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TNFα increases the degradation of pyruvate dehydrogenase kinase 4 by the Lon protease to support proinflammatory genes.
Boutagy NE, Fowler JW, Grabinska KA, Cardone R, Sun Q, Vazquez KR, Whalen MB, Zhu X, Chakraborty R, Martin KA, Simons M, Romanoski CE, Kibbey RG, Sessa WC. Boutagy NE, et al. Among authors: zhu x. Proc Natl Acad Sci U S A. 2023 Sep 19;120(38):e2218150120. doi: 10.1073/pnas.2218150120. Epub 2023 Sep 11. Proc Natl Acad Sci U S A. 2023. PMID: 37695914 Free PMC article.
FGFR1 SUMOylation coordinates endothelial angiogenic signaling in angiogenesis.
Zhu X, Qiu C, Wang Y, Jiang Y, Chen Y, Fan L, Ren R, Wang Y, Chen Y, Feng Y, Zhou X, Zhu Y, Ge Z, Lai D, Qin L, Simons M, Yu L. Zhu X, et al. Among authors: zhu y. Proc Natl Acad Sci U S A. 2022 Jun 28;119(26):e2202631119. doi: 10.1073/pnas.2202631119. Epub 2022 Jun 21. Proc Natl Acad Sci U S A. 2022. PMID: 35733256 Free PMC article.
Acetate controls endothelial-to-mesenchymal transition.
Zhu X, Wang Y, Soaita I, Lee HW, Bae H, Boutagy N, Bostwick A, Zhang RM, Bowman C, Xu Y, Trefely S, Chen Y, Qin L, Sessa W, Tellides G, Jang C, Snyder NW, Yu L, Arany Z, Simons M. Zhu X, et al. Cell Metab. 2023 Jul 11;35(7):1163-1178.e10. doi: 10.1016/j.cmet.2023.05.010. Epub 2023 Jun 15. Cell Metab. 2023. PMID: 37327791 Free PMC article.
Endothelial FIS1 DeSUMOylation Protects Against Hypoxic Pulmonary Hypertension.
Zhou X, Jiang Y, Wang Y, Fan L, Zhu Y, Chen Y, Wang Y, Zhu Y, Wang H, Pan Z, Li Z, Zhu X, Ren R, Ge Z, Lai D, Lai EY, Chen T, Wang K, Liang P, Qin L, Liu C, Qiu C, Simons M, Yu L. Zhou X, et al. Among authors: zhu x, zhu y. Circ Res. 2023 Sep;133(6):508-531. doi: 10.1161/CIRCRESAHA.122.321200. Epub 2023 Aug 17. Circ Res. 2023. PMID: 37589160
SUMOylation Fine-Tunes Endothelial HEY1 in the Regulation of Angiogenesis.
Ren R, Ding S, Ma K, Jiang Y, Wang Y, Chen J, Wang Y, Kou Y, Fan X, Zhu X, Qin L, Qiu C, Simons M, Wei X, Yu L. Ren R, et al. Among authors: zhu x. Circ Res. 2024 Jan 19;134(2):203-222. doi: 10.1161/CIRCRESAHA.123.323398. Epub 2024 Jan 3. Circ Res. 2024. PMID: 38166414
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