Xie H - Search Results

1

Development of Potent and Selective Coactivator-Associated Arginine Methyltransferase 1 (CARM1) Degraders.

Xie H, Bacabac MS, Ma M, Kim EJ, Wang Y, Wu W, Li L, Xu W, Tang W. Xie H, et al. J Med Chem. 2023 Sep 28;66(18):13028-13042. doi: 10.1021/acs.jmedchem.3c00982. Epub 2023 Sep 13. J Med Chem. 2023. PMID: 37703322 Free PMC article.

2

Development of selective small molecule MDM2 degraders based on nutlin.

Wang B, Wu S, Liu J, Yang K, Xie H, Tang W. Wang B, et al. Among authors: xie h. Eur J Med Chem. 2019 Aug 15;176:476-491. doi: 10.1016/j.ejmech.2019.05.046. Epub 2019 May 17. Eur J Med Chem. 2019. PMID: 31128449

3

Development of the first small molecule histone deacetylase 6 (HDAC6) degraders.

Yang K, Song Y, Xie H, Wu H, Wu YT, Leisten ED, Tang W. Yang K, et al. Among authors: xie h. Bioorg Med Chem Lett. 2018 Aug 1;28(14):2493-2497. doi: 10.1016/j.bmcl.2018.05.057. Epub 2018 May 30. Bioorg Med Chem Lett. 2018. PMID: 29871848

4

Discovery of 2,3'-diindolylmethanes as a novel class of PCSK9 modulators.

Winston-McPherson GN, Xie H, Yang K, Li X, Shu D, Tang W. Winston-McPherson GN, et al. Among authors: xie h. Bioorg Med Chem Lett. 2019 Aug 15;29(16):2345-2348. doi: 10.1016/j.bmcl.2019.06.014. Epub 2019 Jun 12. Bioorg Med Chem Lett. 2019. PMID: 31227343 Free PMC article.

5

From methylene bridged diindole to carbonyl linked benzimidazoleindole: Development of potent and metabolically stable PCSK9 modulators.

Xie H, Yang K, Winston-McPherson GN, Stapleton DS, Keller MP, Attie AD, Smith KA, Tang W. Xie H, et al. Eur J Med Chem. 2020 Nov 15;206:112678. doi: 10.1016/j.ejmech.2020.112678. Epub 2020 Aug 4. Eur J Med Chem. 2020. PMID: 32823006 Free PMC article.

6

Development of Substituted Phenyl Dihydrouracil as the Novel Achiral Cereblon Ligands for Targeted Protein Degradation.

Xie H, Li C, Tang H, Tandon I, Liao J, Roberts BL, Zhao Y, Tang W. Xie H, et al. J Med Chem. 2023 Feb 23;66(4):2904-2917. doi: 10.1021/acs.jmedchem.2c01941. Epub 2023 Feb 7. J Med Chem. 2023. PMID: 36749666 Free PMC article.

7

A platform for the rapid synthesis of molecular glues (Rapid-Glue) under miniaturized conditions for direct biological screening.

Li J, Li C, Zhang Z, Zhang Z, Wu Z, Liao J, Wang Z, McReynolds M, Xie H, Guo L, Fan Q, Peng J, Tang W. Li J, et al. Among authors: xie h. Eur J Med Chem. 2023 Oct 5;258:115567. doi: 10.1016/j.ejmech.2023.115567. Epub 2023 Jun 20. Eur J Med Chem. 2023. PMID: 37390512 Free PMC article.

8

Development of Multifunctional Histone Deacetylase 6 Degraders with Potent Antimyeloma Activity.

Wu H, Yang K, Zhang Z, Leisten ED, Li Z, Xie H, Liu J, Smith KA, Novakova Z, Barinka C, Tang W. Wu H, et al. Among authors: xie h. J Med Chem. 2019 Aug 8;62(15):7042-7057. doi: 10.1021/acs.jmedchem.9b00516. Epub 2019 Jul 17. J Med Chem. 2019. PMID: 31271281

9

A Cell-Based Target Engagement Assay for the Identification of Cereblon E3 Ubiquitin Ligase Ligands and Their Application in HDAC6 Degraders.

Yang K, Zhao Y, Nie X, Wu H, Wang B, Almodovar-Rivera CM, Xie H, Tang W. Yang K, et al. Among authors: xie h. Cell Chem Biol. 2020 Jul 16;27(7):866-876.e8. doi: 10.1016/j.chembiol.2020.04.008. Epub 2020 May 14. Cell Chem Biol. 2020. PMID: 32413286 Free PMC article.

10

Rhodium(I)-Catalyzed Benzannulation of Heteroaryl Propargylic Esters: Synthesis of Indoles and Related Heterocycles.

Li X, Xie H, Fu X, Liu JT, Wang HY, Xi BM, Liu P, Xu X, Tang W. Li X, et al. Among authors: xie h. Chemistry. 2016 Jul 18;22(30):10410-4. doi: 10.1002/chem.201602088. Epub 2016 Jun 20. Chemistry. 2016. PMID: 27189811 Free PMC article.

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