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Deep spatial-omics analysis of Head & Neck carcinomas provides alternative therapeutic targets and rationale for treatment failure.
Causer A, Tan X, Lu X, Moseley P, Teoh SM, Molotkov N, McGrath M, Kim T, Simpson PT, Perry C, Frazer IH, Panizza B, Ladwa R, Nguyen Q, Gonzalez-Cruz JL. Causer A, et al. Among authors: simpson pt. NPJ Precis Oncol. 2023 Sep 13;7(1):89. doi: 10.1038/s41698-023-00444-2. NPJ Precis Oncol. 2023. PMID: 37704757 Free PMC article.
LobSig is a multigene predictor of outcome in invasive lobular carcinoma.
McCart Reed AE, Lal S, Kutasovic JR, Wockner L, Robertson A, de Luca XM, Kalita-de Croft P, Dalley AJ, Coorey CP, Kuo L, Ferguson K, Niland C, Miller G, Johnson J, Reid LE, Males R, Saunus JM, Chenevix-Trench G, Coin L, Lakhani SR, Simpson PT. McCart Reed AE, et al. Among authors: simpson pt. NPJ Breast Cancer. 2019 Jun 27;5:18. doi: 10.1038/s41523-019-0113-y. eCollection 2019. NPJ Breast Cancer. 2019. PMID: 31263747 Free PMC article.
Using whole-genome sequencing data to derive the homologous recombination deficiency scores.
de Luca XM, Newell F, Kazakoff SH, Hartel G, McCart Reed AE, Holmes O, Xu Q, Wood S, Leonard C, Pearson JV, Lakhani SR, Waddell N, Nones K, Simpson PT. de Luca XM, et al. Among authors: simpson pt. NPJ Breast Cancer. 2020 Aug 7;6:33. doi: 10.1038/s41523-020-0172-0. eCollection 2020. NPJ Breast Cancer. 2020. PMID: 32818150 Free PMC article.
Epigenome erosion and SOX10 drive neural crest phenotypic mimicry in triple-negative breast cancer.
Saunus JM, De Luca XM, Northwood K, Raghavendra A, Hasson A, McCart Reed AE, Lim M, Lal S, Vargas AC, Kutasovic JR, Dalley AJ, Miranda M, Kalaw E, Kalita-de Croft P, Gresshoff I, Al-Ejeh F, Gee JMW, Ormandy C, Khanna KK, Beesley J, Chenevix-Trench G, Green AR, Rakha EA, Ellis IO, Nicolau DV Jr, Simpson PT, Lakhani SR. Saunus JM, et al. Among authors: simpson pt. NPJ Breast Cancer. 2022 May 2;8(1):57. doi: 10.1038/s41523-022-00425-x. NPJ Breast Cancer. 2022. PMID: 35501337 Free PMC article.
B7-H3 Expression in Breast Cancer and Brain Metastasis.
Joshi V, Beecher K, Lim M, Stacey A, Feng Y, Jat PS, Duijf PHG, Simpson PT, Lakhani SR, McCart Reed AE. Joshi V, et al. Among authors: simpson pt. Int J Mol Sci. 2024 Apr 3;25(7):3976. doi: 10.3390/ijms25073976. Int J Mol Sci. 2024. PMID: 38612786 Free PMC article.
Meta-analysis of the global gene expression profile of triple-negative breast cancer identifies genes for the prognostication and treatment of aggressive breast cancer.
Al-Ejeh F, Simpson PT, Sanus JM, Klein K, Kalimutho M, Shi W, Miranda M, Kutasovic J, Raghavendra A, Madore J, Reid L, Krause L, Chenevix-Trench G, Lakhani SR, Khanna KK. Al-Ejeh F, et al. Among authors: simpson pt. Oncogenesis. 2014 Apr 21;3(4):e100. doi: 10.1038/oncsis.2014.14. Oncogenesis. 2014. PMID: 24752235 Free PMC article.
Metaplastic breast cancers frequently express immune checkpoint markers FOXP3 and PD-L1.
Kalaw E, Lim M, Kutasovic JR, Sokolova A, Taege L, Johnstone K, Bennett J, Saunus JM, Niland C, Ferguson K, Gresshoff I, Bettington M, Pathmanathan N, Tse GM, Papadimos D, Pathmanathan R, Harris G, Yamaguchi R, Tan PH, Fox S, O'Toole SA, Simpson PT, Lakhani SR, McCart Reed AE. Kalaw E, et al. Among authors: simpson pt. Br J Cancer. 2020 Nov;123(11):1665-1672. doi: 10.1038/s41416-020-01065-3. Epub 2020 Sep 17. Br J Cancer. 2020. PMID: 32939056 Free PMC article.
171 results