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Page 1
Identification of GDC-1971 (RLY-1971), a SHP2 Inhibitor Designed for the Treatment of Solid Tumors.
Taylor AM, Williams BR, Giordanetto F, Kelley EH, Lescarbeau A, Shortsleeves K, Tang Y, Walters WP, Arrazate A, Bowman C, Brophy E, Chan EW, Deshmukh G, Greisman JB, Hunsaker TL, Kipp DR, Saenz Lopez-Larrocha P, Maddalo D, Martin IJ, Maragakis P, Merchant M, Murcko M, Nisonoff H, Nguyen V, Nguyen V, Orozco O, Owen C, Pierce L, Schmidt M, Shaw DE, Smith S, Therrien E, Tran JC, Watters J, Waters NJ, Wilbur J, Willmore L. Taylor AM, et al. Among authors: walters wp. J Med Chem. 2023 Oct 12;66(19):13384-13399. doi: 10.1021/acs.jmedchem.3c00483. Epub 2023 Sep 29. J Med Chem. 2023. PMID: 37774359
Prediction of 'drug-likeness'.
Walters WP, Murcko MA. Walters WP, et al. Adv Drug Deliv Rev. 2002 Mar 31;54(3):255-71. doi: 10.1016/s0169-409x(02)00003-0. Adv Drug Deliv Rev. 2002. PMID: 11922947
Guiding molecules towards drug-likeness.
Egan WJ, Walters WP, Murcko MA. Egan WJ, et al. Among authors: walters wp. Curr Opin Drug Discov Devel. 2002 Jul;5(4):540-9. Curr Opin Drug Discov Devel. 2002. PMID: 12197312 Review.
Alpha shock.
Murcko MA, Walters WP. Murcko MA, et al. Among authors: walters wp. J Comput Aided Mol Des. 2012 Jan;26(1):97-102. doi: 10.1007/s10822-011-9532-z. Epub 2012 Jan 4. J Comput Aided Mol Des. 2012. PMID: 22215490 Free PMC article. No abstract available.
Virtual Chemical Libraries.
Walters WP. Walters WP. J Med Chem. 2019 Feb 14;62(3):1116-1124. doi: 10.1021/acs.jmedchem.8b01048. Epub 2018 Sep 10. J Med Chem. 2019. PMID: 30148631 Review.
Defining Levels of Automated Chemical Design.
Goldman B, Kearnes S, Kramer T, Riley P, Walters WP. Goldman B, et al. Among authors: walters wp. J Med Chem. 2022 May 26;65(10):7073-7087. doi: 10.1021/acs.jmedchem.2c00334. Epub 2022 May 5. J Med Chem. 2022. PMID: 35511951 Free PMC article. Review.
57 results